| Title | Epigenetic regulation of an adverse metabolic phenotype in polycystic ovary syndrome: the impact of the leukocyte methylation of PPARGC1A promoter |
| Authors | Zhao, Hongcui Zhao, Yue Ren, Yun Li, Min Li, Tianjie Li, Rong Yu, Yang Qiao, Jie |
| Affiliation | Peking Univ, Hosp 3, Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China. Peking Univ, Hosp 3, Beijing Key Lab Reprod Endocrinol & Assisted Repr, Ctr Reprod Med, Beijing, Peoples R China. Peking Univ, Hosp 3, Dept Obstet & Gynecol, 49 HuaYuan North Rd, Beijing 100191, Peoples R China. |
| Keywords | ATPIII BMI lipid profile metabolic risk mitochondrial biogenesis MITOCHONDRIAL-DNA CONTENT INSULIN-RESISTANCE CARDIOVASCULAR-DISEASE EXPRESSION PATHOGENESIS COACTIVATOR HEALTH BLOOD WOMEN GENE |
| Issue Date | 2017 |
| Publisher | FERTILITY AND STERILITY |
| Citation | FERTILITY AND STERILITY.2017,107(2),467-+. |
| Abstract | Objective: To investigate PPARGC1A promoter methylation and mitochondria DNA (mtDNA) content in the leukocytes of women with polycystic ovary syndrome (PCOS) and analyze the relationship between these indices and metabolic risk for women with PCOS. Design: Cross-sectional study. Setting: University hospital. Patient(s): A total of 175 women with PCOS and 127 healthy controls. Intervention(s): None. Main Outcome Measure(s): Women with and without PCOS classified using the typical metabolic risk criteria of the National Cholesterol Education Program's Adult Treatment Panel III report (ATPIII), methylation of PPARGC1A promoter tested by methylationspecific polymerase chain reaction, and mtDNA content confirmed by quantitative polymerase chain reaction (PCR). Result(s): PPARGC1A promoter methylation was specifically increased, but mtDNA content was specifically decreased in women with PCOS compared with the control women after adjustment for body mass index. Moreover, in women with PCOS who have increased metabolic risk, the differences in PPARGC1A promoter methylation and mitochondrial content were aggravated. Conclusion(s): In conclusion, PPARGC1Apromotermethylation and mitochondrial content were found to be potential biomarkers for the prediction ofmetabolic risk inwomen with PCOS. (C) 2016 TheAuthors. Published by Elsevier Inc. on behalf of theAmerican Society for ReproductiveMedicine. |
| URI | http://hdl.handle.net/20.500.11897/475348 |
| ISSN | 0015-0282 |
| DOI | 10.1016/j.fertnstert.2016.10.039 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
