| Title | The Steroidogenic Acute Regulatory Protein ( StAR) Is Regulated by the H19/let-7 Axis |
| Authors | Men, Yi Fan, Yanhong Shen, Yuanyuan Lu, Lingeng Kallen, Amanda N. |
| Affiliation | Yale Sch Med, Dept Obstet Gynecol & Reproduct Sci, New Haven, CT 06510 USA. Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT 06510 USA. Sichuan Univ, West China Hosp Stomatol, Dept Head & Neck Surg, State Key Lab Oral Dis, Sichuan 610041, Peoples R China. Peking Univ Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100191, Peoples R China. Affiliated Hosp Chongqing Med Univ 1, Dept Endocrine & Breast Surg, Chongqing 400016, Peoples R China. Dept Obstet Gynecol & Reprod Sci, 333 Cedar St,Box 208063, New Haven, CT 06512 USA. |
| Keywords | GENE-EXPRESSION H19 GENE CELLS MICRORNAS LET-7 |
| Issue Date | 2017 |
| Publisher | ENDOCRINOLOGY |
| Citation | ENDOCRINOLOGY.2017,158(2),402-409. |
| Abstract | The steroidogenic acute regulatory protein (StAR) governs the rate-limiting step in steroidogenesis, and its expression varies depending on the needs of the specific tissue. Tight control of steroid production is essential for multiple processes involved in reproduction, including follicular development, ovulation, and endometrial synchronization. Recently, there has been a growing interest in the role of noncoding RNAs in the regulation of reproduction. Here we demonstrate that StAR is a novel target of the microRNA let-7, which itself is regulated by the long noncoding RNA (lncRNA) H19. Using human and murine cell lines, we show that overexpression of H19 stimulates StAR expression by antagonizing let-7, which inhibits StAR at the post-transcriptional level. Our results uncover a novel mechanism underlying the regulation of StAR expression and represent the first example of lncRNA-mediated control of the rate-limiting step of steroidogenesis. This work thus adds to the body of literature describing the multiple roles in oncogenesis, cellular growth, glucose metabolism, and now regulation of steroidogenesis, of this complex lncRNA. |
| URI | http://hdl.handle.net/20.500.11897/475346 |
| ISSN | 0013-7227 |
| DOI | 10.1210/en.2016-1340 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
