| Title | Design, synthesis and biological evaluation of (E)-3,4-dihydroxystyryl 4-acylaminophenethyl sulfone, sulfoxide derivatives as dual inhibitors of HIV-1 CCR5 and integrase |
| Authors | Sun, Yixing Xu, Weisi Fan, Ningning Sun, Xuefeng Ning, Xianling Ma, Liying Liu, Junyi Wang, Xiaowei |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China. Collaborat Innovat Ctr Diag & Treatment Infect Di, Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China. Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China. Ma, LY (reprint author), Collaborat Innovat Ctr Diag & Treatment Infect Di, Chinese Ctr Dis Control & Prevent, Natl Ctr AIDS STD Control & Prevent, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China. |
| Keywords | HIV dual inhibitors CCR5 receptor HIV integrase Sulfones Sulfoxides |
| Issue Date | 2017 |
| Publisher | BIOORGANIC & MEDICINAL CHEMISTRY |
| Citation | BIOORGANIC & MEDICINAL CHEMISTRY.2017,25(3),1076-1084. |
| Abstract | Aiming at the limited effectiveness of current clinical therapeutic effect of AIDS, novel series of compounds bearing (E)-3,4-dihydroxystyryl sulfone (or sulfoxide) and anilide fragments were designed and synthesized as dual inhibitors of HIV-1 CCR5/IN. The biological results indicated that several target compounds showed inhibitory activity against HIV-1 Bal (R5) infection in TZM-bI cells. Besides targeting the chemokine receptor on the host cell surface, they also displayed binding affinities with HIV-1 integrase using the surface plasmon resonance (SPR) binding assays. Molecular docking studies have inferred the possible binding mode of target compounds against integrase. These data demonstrate that the structure of (E)-3,4-dihydroxystyryl sulfone and sulfoxide derivatives have the potential to derive potent dual inhibitors of HIV-1 Integrase and CCR5. (C) 2017 Elsevier Ltd. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/475293 |
| ISSN | 0968-0896 |
| DOI | 10.1016/j.bmc.2016.12.035 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
