| Title | A perspective of chronic low exposure of arsenic on non -working women: Risk of hypertension |
| Authors | Yu, Yanxin Guo, Yunhe Zhang, Jingxu Xie, Jing Zhu, Yibing Yan, Jingjing Wang, Bin Li, Zhiwen |
| Affiliation | Beijing Normal Univ, Sch Environm, Beijing 100875, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Child Adolescent & Womens Hlth, Beijing 100191, Peoples R China. Peking Univ, Inst Reprod & Child Health Key Lab Reprod Hlth, Natl Hlth & Family Planning Commiss Peoples Repub, Beijing 100191, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China. |
| Keywords | Arsenic Hypertension Hair Single nucleotide polymorphism Phase II metabolism Non-working women POLYCYCLIC AROMATIC-HYDROCARBONS HUMAN HAIR OXIDATIVE STRESS DRINKING-WATER HUMAN-POPULATIONS HEAVY-METALS SCALP HAIR ICP-MS BANGLADESH CHINA |
| Issue Date | 2017 |
| Publisher | SCIENCE OF THE TOTAL ENVIRONMENT |
| Citation | SCIENCE OF THE TOTAL ENVIRONMENT.2017,580,69-73. |
| Abstract | The relationship between arsenic (As) exposure and hypertension risk are extensively studied. The As content in scalp hair has been used as a reliable indicator of population for long-rime exposure from different sources. Therefore, we investigated the association between hair As concentration and hypertension risk, as well as the potential modifying effects of single nucleotide polymorphisms (SNPs) related to phase II metabolism enzyme genes. We recruited 398 non-working Women in Shanxi Province, northern China, from Aug 2012 to May 2013, including 163 subjects with hypertension (cases) and 235 healthy controls. Scalp hair and blood samples were collected from each subject. We analyzed the As concentrations of similar to 24-cm-long strands of hair representing the two most recent years of growth and SNPs of three genes (epoxide hydrolase 1, N-acetyltransferase 2, and glutathione S-transferase P1) in each subject. The results revealed that the hair As concentration of this population was significantly lower than in populations living near high As polluted sources in China and other countries. The median As concentration (inter-quartile range) of hair in the cases (i.e. 0.211 [0.114-0.395] mu g/g hair) was higher than in the controls (i.e. 0.101 [0.048-0.227] mu/g hair). Higher hair As concentrations were associated with an elevated hypertension risk, with an adjusted odds ratio of 2.55 [95% confidence interval: 1.55-4.20]. No interaction effects between hair As concentration and SNPs related to phase II metabolism enzymes on hypertension risk were observed. It was concluded that chronic low exposure level of As might be associated with hypertension risk among the study subjects. (C) 2016 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/475115 |
| ISSN | 0048-9697 |
| DOI | 10.1016/j.scitotenv.2016.11.204 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
