| Title | Asymmetric Total Synthesis of (-)-Aspidophylline A |
| Authors | Wang, Taimin Duan, Xiaoguang Zhao, Hua Zhai, Shengxian Tao, Cheng Wang, Huifei Li, Yun Cheng, Bin Zhai, Hongbin |
| Affiliation | Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. Peking Univ, Sch Chem Biol & Biotechnol, Key Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China. Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China. Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China. Zhai, HB (reprint author), Peking Univ, Sch Chem Biol & Biotechnol, Key Lab Chem Genom, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China. Zhai, HB (reprint author), Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China. |
| Keywords | CONCISE TOTAL-SYNTHESIS FORMAL TOTAL-SYNTHESIS AKUAMMILINE ALKALOIDS NITROGEN ASSISTANCE GOLD CATALYSIS ENOL ETHERS CYCLIZATION (+/-)-ASPIDOPHYLLINE (+/-)-STRICTAMINE (+)-SCHOLARISINE |
| Issue Date | 2017 |
| Publisher | ORGANIC LETTERS |
| Citation | ORGANIC LETTERS.2017,19(7),1650-1653. |
| Abstract | An asymmetric total synthesis of (-)-aspidophylline A has been accomplished. The key transformations include an asymmetric hydride transfer hydrogenation of an alpha-beta-acetylenic ketone and a cationic gold(I)-catalyzed 6-exo-dig cyclization involving an alkynylindole/aminal formation cascade, which enables stereoselective establishment,of the requisite quaternary carbon center. |
| URI | http://hdl.handle.net/20.500.11897/474064 |
| ISSN | 1523-7060 |
| DOI | 10.1021/acs.orglett.7b00448 |
| Indexed | SCI(E) |
| Appears in Collections: | 化学生物学与生物技术学院 |
