| Title | Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity |
| Authors | Li, Wei Li, Hua Zhang, Liyuan Hu, Min Li, Fang Deng, Jieqiong An, Mingxing Wu, Siqi Ma, Rui Lu, Jiachun Zhou, Yifeng |
| Affiliation | Soochow Univ, Coll Med, Dept Genet, Suzhou 215123, Peoples R China. Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China. Soochow Univ, Affiliated Hosp 2, Dept Radiotherapy & Oncol, San Xiang Rd 1055, Suzhou 215004, Peoples R China. Soochow Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, San Xiang Rd 1055, Suzhou 215004, Peoples R China. Guangzhou Med Univ, Inst Chem Carcinogenesis, State Key Lab Resp Dis, Guangzhou 510182, Guangdong, Peoples R China. Soochow Univ, Coll Med, Suzhou 215123, Peoples R China. |
| Keywords | gene regulation heterogeneous nuclear ribonucleoprotein (hnRNP) long noncoding RNA (long ncRNA lncRNA) p53 paclitaxel (taxol) Lasp1 endometrial cancer INFLUENCES ZYXIN LOCALIZATION SQUAMOUS-CELL CARCINOMA SH3 DOMAIN PROTEIN-1 BREAST-CANCER ESOPHAGEAL ADENOCARCINOMA EXPRESSION PROLIFERATION MIGRATION LIM CHROMATIN |
| Issue Date | 2017 |
| Publisher | JOURNAL OF BIOLOGICAL CHEMISTRY |
| Citation | JOURNAL OF BIOLOGICAL CHEMISTRY.2017,292(14),5801-5813. |
| Abstract | Thousands of long intergenic non-protein coding RNAs (lincRNAs) have been identified in mammals in genome-wide sequencing studies. Some of these RNAs have been consistently conserved during the evolution of species and could presumably function in important biologic processes. Therefore, we measured the levels of 26 highly conserved lincRNAs in a total of 176 pairs of endometrial carcinoma (EC) and surrounding non-tumor tissues of two distinct Chinese populations. Here, we report that a lincRNA, LINC00672, which possesses an ultra-conserved region, is aberrantly down-regulated during the development of EC. Nevertheless, LINC00672 is a p53-targeting lincRNA acting along with heterogeneous nuclear ribonucleoproteins as a suppressive cofactor, which locally reinforces p53-mediated suppression of LASP1, an evolutionarily conserved neighboring gene of LINC00672 and putatively associated with increased tumor aggressiveness, during anti-tumor processes. LINC00672 overexpression could lower the levels of LASP1 and slow the development of malignant phenotypes of EC both in vitro and in vivo. Moreover, LINC00672 significantly increased the 50% inhibitory concentration of paclitaxel in EC cells and increased the sensitivity of xenograft mice to paclitaxel. These findings indicate that LINC00672 can influence LASP1 expression as a locus-restricted cofactor for p53-mediated gene suppression, thus impacting EC malignancies and chemosensitivity to paclitaxel. |
| URI | http://hdl.handle.net/20.500.11897/474062 |
| ISSN | 0021-9258 |
| DOI | 10.1074/jbc.M116.758508 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
