| Title | Intracerebral hemorrhage location and outcome among INTERACT2 participants |
| Authors | Delcourt, Candice Sato, Shoichiro Zhang, Shihong Sandset, Else Charlotte Zheng, Danni Chen, Xiaoying Hackett, Maree L. Arima, Hisatomi Hata, Jun Heeley, Emma Salman, Rustam Al-Shahi Robinson, Thompson Davies, Leo Lavados, Pablo M. Lindley, Richard I. Stapf, Christian Chalmers, John Anderson, Craig S. |
| Affiliation | Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, Australia. Royal Prince Alfred Hosp, Camperdown, Australia. Natl Cerebral & Cardiovascular Ctr, Osaka, Japan. Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China. Oslo Univ Hosp, Oslo, Norway. Univ Cent Lancashire, Preston, Lancs, England. Fukuoka Univ, Fac Med, Dept Prevent Med & Publ Hlth, Fukuoka, Japan. Kyushu Univ, Ctr Cohort Studies, Grad Sch Med Sci, Fukuoka, Japan. Univ Edinburgh, Ctr Clin Brain Sci, Div Clin Neurosci, Edinburgh, Midlothian, Scotland. Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 7RH, Leics, England. Univ Leicester, NIHR Biomed Res Unit Cardiovasc Dis, Leicester LE1 7RH, Leics, England. Univ Desarrollo, Fac Med Clin Alemana, Clin Alemana Santiago, Concepcion, Chile. Univ Chile, Fac Med, Santiago, Chile. Westmead Hosp, Sch Clin, Westmead, NSW, Australia. Univ Montreal, Ctr Hosp, Ctr Rech, Montreal, PQ H3C 3J7, Canada. Univ Montreal, Dept Neurosci, Montreal, PQ H3C 3J7, Canada. Peking Univ, Hlth Sci Ctr, George Inst China, Beijing, Peoples R China. |
| Keywords | QUALITY-OF-LIFE INTERNAL CAPSULE CLINICAL-FEATURES STROKE POPULATION PREDICTION MORTALITY OLDER SCORE PAIN |
| Issue Date | 2017 |
| Publisher | NEUROLOGY |
| Citation | NEUROLOGY.2017,88(15),1408-1414. |
| Abstract | Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Associations between ICH sites and poor outcomes (death [6] or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90 days were assessed in logistic regression models. Results: Of 2,066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (<= 0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all health-related quality of life domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability, and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusion: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule. |
| URI | http://hdl.handle.net/20.500.11897/474040 |
| ISSN | 0028-3878 |
| DOI | 10.1212/WNL.0000000000003771 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
