| Title | Nomograms for predicting long-term overall survival and cancer-specific survival in patients with major salivary gland cancer: a population-based study |
| Authors | Li, Yun Ju, Jun Liu, Xiaoxiao Gao, Tao Wang, Zhidong Ni, Qianwei Ma, Chao Zhao, Zhenyan Ren, Yixiong Sun, Moyi |
| Affiliation | Fourth Mil Med Univ, State Key Lab Mil Stomatol, Natl Clin Res Ctr Oral Dis,Sch Stomatol, Shaanxi Clin Res Ctr Oral Dis,Dept Oral & Maxillo, Xian, Peoples R China. Navy Gen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China. Peking Univ, Hosp 1, Fengtai Hosp, Dept Stomatol, Beijing, Peoples R China. First Hosp Yu Lin, Dept Stomatol, Yulin, Shaanxi, Peoples R China. Fourth Mil Med Univ, Sch Prevent Med, Dept Hlth Stat, Xian, Peoples R China. |
| Keywords | nomograms major salivary gland cancer overall survival cancer-specific survival head and neck SQUAMOUS-CELL CARCINOMA RADIATION-THERAPY COMPETING RISK PROGNOSTIC-FACTORS TUMORS MANAGEMENT MALIGNANCIES OUTCOMES SURGERY HEAD |
| Issue Date | 2017 |
| Publisher | ONCOTARGET |
| Citation | ONCOTARGET.2017,8(15),24469-24482. |
| Abstract | In this study, we aimed to develop and validate nomograms for predicting long-term overall survival (OS) and cancer-specific survival (CSS) in major salivary gland cancer (MSGC) patients. These nomograms were developed using a retrospective cohort (N=4218) from the Surveillance, Epidemiology, and End Results (SEER) database, and externally validated using an independent data cohort (N=244). We used univariate, and multivariate analyses, and cumulative incidence function to select the independent prognostic factors of OS and CSS. Index of concordance (c-index) and calibration plots were used to estimate the nomograms' predictive accuracy. The median follow-up period was 34 months (1-119 months). Of 4218 MSGC patients, 1320 (31.3%) died by the end of the follow-up; of these 1320 patients, 883 (20.9%) died of MSGC. The OS nomogram, which had a c-index of 0.817, was based on nine variables: age, sex, tumor site, tumor grade, surgery performed, radiation therapy and TNM classifications. The CSS nomogram, which had a c-index of 0.829, was based on the same nine variables plus race. External validation c-indexes were 0.829 and 0.807 for OS and CSS, respectively. Based on SEER database, we have developed nomograms predicting five- and eight-years OS and CSS for MSGC patients with perfect accuracy. These nomograms will help clinicians customize treatment and monitoring strategies in MSGC patients. |
| URI | http://hdl.handle.net/20.500.11897/474033 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.14905 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
