| Title | Cardiovascular disease in rheumatoid arthritis: medications and risk factors in China |
| Authors | Li, Chun Wang, X. R. Ji, H. J. Zhang, X. Y. Li, X. F. Wang, L. Z. Wang, C. H. Wang, Y. F. Yang, Rong Wang, G. C. Lu, Xin Zhu, Ping Chen, L. N. Jin, H. T. Liu, J. T. Liu, X. Y. Sun, Lin Chen, H. Y. Wei, Ping Wang, J. X. Cui, L. F. Shu, Rong Liu, B. L. Zhang, Z. L. Li, G. T. Li, Z. B. Yang, Jing Li, J. F. Jia, Bin Zhang, F. X. Tao, J. M. Han, S. L. Lin, J. Y. Wei, M. Q. Liu, X. M. Ke, Dan Hu, S. X. Ye, Cong Yang, X. Y. Li, Hao Huang, C. B. Gao, Ming Lai, Bei Li, X. F. Song, L. J. Wang, Yi Wang, X. Y. Tang, Y. |
| Affiliation | Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, 11 South Xizhimen St, Beijing 100044, Peoples R China. Peking Univ, Dept Rheumatol & Immunol, Shougang Hosp, 9 Jinyuanzhuang St, Beijing 100144, Peoples R China. Shanxi Med Univ, Dept Rheumatol & Immunol, Affiliated Hosp 2, 382 Wuyi Rd, Taiyuan 030001, Peoples R China. Baotou Med Coll, Affiliated Hosp 1, Dept Rheumatol & Immunol, 41 Linyin Rd, Baotou 014010, Peoples R China. China Japan Friendship Hosp, Dept Rheumatol & Immunol, 2 Yinghua Dongjie, Beijing 100029, Peoples R China. Xijing Hosp, Dept Rheumatol & Immunol, 15 Changle Rd, Xian 710032, Peoples R China. Hebei Med Univ, Dept Rheumatol & Immunol, Hosp 2, 215 West Heping Rd, Shijiazhuang 050000, Peoples R China. Peking lthivers, Dept Rheumatol & Immunol, Hosp 3, 49 North Garden Rd, Beijing 100191, Peoples R China. Hebei Med Univ, Dept Rheumatol & Immunol, Hosp 3, 139 Ziqiang Rd, Shijiazhuang 050000, Peoples R China. North China Coal Hosp, Dept Rheumatol & Immunol, Kailuan Hosp, 57 West Xinhua Rd, Tangshan 063000, Peoples R China. Peking Univ, Dept Rheumatol & Immunol, Hosp 1, 8 Xishiku Rd, Beijing 100034, Peoples R China. Peace Hosp, Dept Rheumatol & Immunol, 398 West Zhongshan Rd, Shijiazhuang 050082, Peoples R China. Hebei Handan Cent Hosp, Dept Rheumatol & Immunol, 311 Heping Rd, Handan 056001, Peoples R China. Hebei Peoples Hosp, Dept Rheumatol & Immunol, 348 West Heping Rd, Shijiazhuang 050051, Peoples R China. Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Rheumatol & Immunol, 6 Taoyuan Rd, Nanning 530021, Peoples R China. China Med Univ, Dept Rheumatol & Immunol, Beijing Shunyi Hosp, 3 South Guangrning Rd, Beijing 101300, Peoples R China. Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Rheumatol & Immunol, 1095 Jie Fang Ave, Wuhan 430030, Peoples R China. Sun Yat Sen Univ, Dept Rheumatol & Immunol, Affiliated Hosp 1, 58 Second Zhongshan Rd, Guangzhou 510080, Guangdong, Peoples R China. Beijing Hosp, Dept Rheumatol & Immunol, 1 Dahua Rd, Beijing 100730, Peoples R China. Shandong Univ, Qilu Hosp, Dept Rheumatol & Immunol, 107 Jinan Culture Rd, Jinan 250012, Peoples R China. Lanzhou Univ, Dept Rheumatol & Immunol, Hosp 2, 82 Cuiyingmen Rd, Lanzhou 730030, Peoples R China. Fuwai Hosp, Dept Cardiol, North Lishi Rd, Beijing 100037, Peoples R China. |
| Keywords | Cardiovascular disease Rheumatoid arthritis Risk factor INTERSTITIAL LUNG-DISEASE HYDROXYCHLOROQUINE EVENTS COHORT DRUGS MANAGEMENT RESISTANCE THERAPY |
| Issue Date | 2017 |
| Publisher | CLINICAL RHEUMATOLOGY |
| Citation | CLINICAL RHEUMATOLOGY.2017,36(5),1023-1029. |
| Abstract | This study aims to assess the risk factors of cardiovascular disease (CVD) and to determine the association of traditional and biologic disease-modifying anti-rheumatic drugs (DMARDs) with risk for CVD in Chinese rheumatoid arthritis (RA) patients. A cross-sectional cohort of 2013 RA patients from 21 hospitals around China was established. Medical history of CVD was documented. The patients' social background, clinical manifestations, comorbidities, and medications were also collected. Of the 2013 patients, 256 had CVD with an incidence of 12.7%. Compared with non-CVD controls, RA patients with CVD had a significantly advanced age, long-standing median disease duration, more often male and more deformity joints. Patients with CVD also had higher rates of smoking, rheumatoid nodules, interstitial lung disease, and anemia. The prevalence of comorbidities, including hypothyroidism, diabetes mellitus (DM), hypertension, and hyperlipidemia, was also significant higher in the CVD group. In contrast, patients treated with methotrexate, hydroxychloroquine (HCQ), and TNF blockers had lower incidence of CVD. The multivariate analysis showed that the use of HCQ was a protective factor of CVD, while hypertension, hyperlipidemia, and interstitial lung disease were independent risk factors of CVD. Our study shows that the independent risk factors of CVD include hypertension, hyperlipidemia, and interstitial lung disease. HCQ reduces the risk of CVD in patients with RA. |
| URI | http://hdl.handle.net/20.500.11897/473753 |
| ISSN | 0770-3198 |
| DOI | 10.1007/s10067-017-3596-7 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 首钢医院 第一医院 |
