| Title | Plasma neurofilament light chain levels in Alzheimer's disease |
| Authors | Zhou, Wenjun Zhang, Jie Ye, Fanlong Xu, Guangzheng Su, Hang Su, Yindan Zhang, Xiangyang |
| Affiliation | Fudan Univ, Zhongshan Hosp, Dept Resp Med, Shanghai, Peoples R China. Fudan Univ, Zhongshan Hosp, Dept Neurol, 180 Fenglin Rd, Shanghai 200032, Peoples R China. Xujiahui Community Hlth Serv Ctr, Shanghai, Peoples R China. Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China. Hangzhou Normal Univ, Affiliated High Sch, Hangzhou, Zhejiang, Peoples R China. Peking Univ, Beijing HuiLongGuan Hosp, Beijing, Peoples R China. Fudan Univ, Zhongshan Hosp, Dept Neurol, 180 Fenglin Rd, Shanghai 200032, Peoples R China. Zhang, XY (reprint author), Beijing Hui Long Guan Hosp, Biol Psychiat Ctr, Beijing 100096, Peoples R China. |
| Keywords | Neurofilament light Biomarker Mild cognitive impairment Alzheimer'disease NEURODEGENERATIVE DISEASES CEREBROSPINAL-FLUID CSF METAANALYSIS PROGRESSION BIOMARKERS DEMENTIA PROTEIN BLOOD |
| Issue Date | 2017 |
| Publisher | NEUROSCIENCE LETTERS |
| Citation | NEUROSCIENCE LETTERS.2017,650,60-64. |
| Abstract | Plasma neurofilament light (NFL) levels may be a marker of neuronal injury. We examined whether plasma NFL might be a potential biomarker for the prodromal and dementia stages of AD. Participants included 193 cognitively normal (CN), 198 amnestic mild cognitive impairment (aMCI) and 187 Alzheimer's disease (AD) individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Plasma NFL levels were examined by the Single Molecule array (Simoa) technique. Our results showed significantly increased plasma NFL levels in both AD (50.9 pg/ml) and aMCI (43.0 pg/m1) groups compared to CN (34.7 pg/ml) group (both p < 0.001), but with substantial overlap between the groups. Plasma NFL levels in AD grolip was also markedly increased, compared with aMCI group (p <0.001). Plasma NFL levels were positively associated with age (r = 0.355, p < 0.001) and negatively with global cognition (r = -0.355, p < 0.001) in all subjects. Our results suggest that plasma NFL levels may not be a useful biomarker for the diagnosis of prodromal and dementia stages of AD. (C) 2017 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/473342 |
| ISSN | 0304-3940 |
| DOI | 10.1016/j.neulet.2017.04.027 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京回龙观医院 |
