| Title | Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi-stage genome-wide association study |
| Authors | Zhu, Yimin Zhang, Dandan Zhou, Dan Li, Zhenli Li, Zhiqiang Fang, Le Yang, Min Shan, Zhongyan Li, Hong Chen, Jianhua Zhou, Xianghai Ye, Wei Yu, Senhai Li, Huabin Cai, Libin Liu, Chengguo Zhang, Jie Wang, Lixin Lai, Yaxin Ruan, Liansheng Sun, Zhanhang Zhang, Shuai Wang, Hao Liu, Yi Xu, Yuyang Ling, Jie Xu, Chunxiao Zhang, Yan Lv, Duo Yuan, Zheping Zhang, Jing Zhang, Yingqi Shi, Yongyong lai, Maode |
| Affiliation | Zhejiang Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Hangzhou, Zhejiang, Peoples R China. Zhejiang Univ, Dept Pathol, Sch Med, Hangzhou, Zhejiang, Peoples R China. Key Lab Dis Prote Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China. Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai, Peoples R China. Shanghai Jiao Tong Univ, Inst Social Cognit & Behav Sci, Shanghai, Peoples R China. Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Zhejiang, Peoples R China. Zhejiang Univ, Sch Publ Hlth, Dept Nutr & Food Safety, Hangzhou, Zhejiang, Peoples R China. China Med Univ, Endocrine Inst, Shenyang, Liaoning, Peoples R China. China Med Univ, Liaoning Prov Key Lab Endocrine Dis, Dept Endocrinol & Metab, Hosp 1, Shenyang, Liaoning, Peoples R China. Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China. Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing, Peoples R China. Peking Univ, Diabet Ctr, Beijing, Peoples R China. Wenzhou Med Univ, Sch Lab Med & Life Sci, Minist Educ China, Key Lab Lab Med, Wenzhou, Zhejiang, Peoples R China. Daicun Town Community Hlth Serv Ctr, Hangzhou, Zhejiang, Peoples R China. Xiaoshan Dist Sixth Peoples Hosp, Hangzhou, Zhejiang, Peoples R China. Xiaoshan Dist Third Peoples Hosp, Hangzhou, Zhejiang, Peoples R China. Putuo Dist Peoples Hosp, Zhoushan, Zhejiang, Peoples R China. Zhejiang Univ, Dept Pathol, Sch Med, Hangzhou, Zhejiang, Peoples R China. Lai, MD (reprint author), Key Lab Dis Prote Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China. Shi, YY (reprint author), Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai, Peoples R China. Shi, YY (reprint author), Shanghai Jiao Tong Univ, Inst Social Cognit & Behav Sci, Shanghai, Peoples R China. |
| Keywords | metabolic syndrome genome-wide association study single-nucleotide polymorphism secondary signal gene-environment interaction GENE-ENVIRONMENT INTERACTION DRINKING BEHAVIOR BINDING-SITE RISK TRAITS TRIGLYCERIDES METAANALYSIS POPULATION VARIANTS IMPACT |
| Issue Date | 2017 |
| Publisher | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE |
| Citation | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.2017,21(6),1106-1116. |
| Abstract | Metabolic syndrome (MetS), a cluster of metabolic disturbances that increase the risk for cardiovascular disease and diabetes, was because of genetic susceptibility and environmental risk factors. To identify the genetic variants associated with MetS and metabolic components, we conducted a genome-wide association study followed by replications in totally 12,720 participants from the north, north-eastern and eastern China. In combined analyses, independent of the top known signal at rs651821 on APOA5, we newly identified a secondary triglyceride-associated signal at rs180326 on BUD13 (P-combined = 2.4 x 10(-8)). Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian-specific common variant, was found to be associated with MetS (P-combined = 9.7 x 10(-22)) in Han Chinese. The effects of rs671 on metabolic components were more prominent in drinkers than in non-drinkers. The replicated loci provided information on the genetic basis and mechanisms of MetS and metabolic components in Han Chinese. |
| URI | http://hdl.handle.net/20.500.11897/473182 |
| ISSN | 1582-4934 |
| DOI | 10.1111/jcmm.13042 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
