| Title | Preoperative Prognostic Nutritional Index is a Significant Predictor of Survival with Bladder Cancer after Radical Cystectomy: a retrospective study |
| Authors | Peng, Ding Gong, Yan-Qing Hao, Han He, Zhi-Song Li, Xue-Song Zhang, Cui-Jian Zhou, Li-Qun |
| Affiliation | Peking Univ, Dept Urol, Hosp 1, 8 Xishiku St, Beijing 100034, Peoples R China. Peking Univ, Inst Urol, Beijing 100034, Peoples R China. Natl Urol Canc Ctr, Beijing 100034, Peoples R China. Peking Univ, Urogenital Dis Male Mol Diag & Treatment Ctr, Beijing 100034, Peoples R China. Peking Univ, Dept Urol, Hosp 1, 8 Xishiku St, Beijing 100034, Peoples R China. Zhang, CJ Zhou, LQ (reprint author), Peking Univ, Inst Urol, Beijing 100034, Peoples R China. Zhang, CJ Zhou, LQ (reprint author), Natl Urol Canc Ctr, Beijing 100034, Peoples R China. Zhang, CJ Zhou, LQ (reprint author), Peking Univ, Urogenital Dis Male Mol Diag & Treatment Ctr, Beijing 100034, Peoples R China. |
| Keywords | Prognostic nutritional index Bladder cancer Radical cystectomy Outcomes TO-LYMPHOCYTE RATIO CELL CARCINOMA MONOCYTE RATIO OUTCOMES INFLAMMATION MARKER IMPACT PNI |
| Issue Date | 2017 |
| Publisher | BMC CANCER |
| Citation | BMC CANCER.2017,17. |
| Abstract | Background: To explore the prognostic significance of preoperative prognostic nutritional index (PNI) in bladder cancer after radical cystectomy and compare the prognostic ability of inflammation-based indices. Methods: We retrospectively analyzed data for 516 patients with bladder cancer who underwent radical cystectomy in our institution between 2006 to 2012. Clinicopathologic characteristics and inflammation-based indices (PNI, neutrophil/lymphocyte ratio [NLR], platelet/lymphocyte ratio [PLR], lymphocyte/monocyte ratio [LMR]) were evaluated by pre-treatment measurements. Overall survival (OS) and progression-free survival (PFS) were estimated by the Kaplan-Meier method and compared by log-rank test. Multivariate analysis with a Cox proportional hazards model was used to confirm predictors identified on univariate analysis. The association between clinicopathological characteristics and PNI or NLR was tested. Results: Among the 516 patients, the median follow-up was 37 months (interquartile range 20 to 56). On multivariate analysis, PNI and NLR independently predicted OS (PNI: hazard ratio [HR] = 1.668, 95% CI: 1.147-2.425, P = 0.007; NLR: HR = 1.416, 95% CI: 1.094-2.016, P = 0.0149) and PFS (PNI: HR = 1.680, 95% CI: 1.092-2.005, P = 0.015; NLR: HR = 1.550, 95% CI: 1.140-2.388, P = 0.008). Low PNI predicted worse OS for all pathological stages and PFS for T1 and T2 stages. Low PNI was associated with older age (> 65 years), muscle-invasive bladder cancer, high American Society of Anesthesiologists grade and anemia. Conclusion: PNI and NLR were independent predictors of OS and PFS for patients with bladder cancer after radical cystectomy and PNI might be a novel reliable biomarker for bladder cancer. |
| URI | http://hdl.handle.net/20.500.11897/472902 |
| ISSN | 1471-2407 |
| DOI | 10.1186/s12885-017-3372-8 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
