| Title | Lipid vesicles containing transferrin receptor binding peptide TfR-T-12 and octa-arginine conjugate stearyl-R-8 efficiently treat brain glioma along with glioma stem cells |
| Authors | Mu, Li-Min Bu, Ying-Zi Liu, Lei Xie, Hong-Jun Ju, Rui-Jun Wu, Jia-Shuan Zeng, Fan Zhao, Yao Zhang, Jing-Ying Lu, Wan-Liang |
| Affiliation | Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Syst, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China. Peking Univ, Sch Pharmaceut Sci, Beijing, Peoples R China. Beijing Inst Petrochem Technol, Dept Pharmaceut Engn, Beijing, Peoples R China. Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Syst, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China. Lu, WL (reprint author), Peking Univ, Sch Pharmaceut Sci, Beijing, Peoples R China. |
| Keywords | DRUG TRANSPORT CANCER DELIVERY BARRIER TARGET MITOCHONDRIA APOPTOSIS ANTIBODY TUBULIN SYSTEM |
| Issue Date | 2017 |
| Publisher | SCIENTIFIC REPORTS |
| Citation | SCIENTIFIC REPORTS.2017,7. |
| Abstract | Surgery and radiotherapy cannot fully remove brain glioma; thus, chemotherapy continues to play an important role in treatment of this illness. However, because of the restriction of the blood-brain barrier (BBB) and the regeneration of glioma stem cells, post-chemotherapy relapse usually occurs. Here, we report a potential solution to these issues that involves a type of novel multifunctional vinblastine liposomes equipped with transferrin receptor binding peptide TfR-T-12 and octa-arginine conjugate stearyl-R-8. Studies were performed on brain glioma and glioma stem cells in vitro and were verified in brain glioma-bearing mice. The liposomes were transported across the BBB, killing brain glioma and glioma stem cells via the induction of necrosis, apoptosis and autophagy. Furthermore, we reveal the molecular mechanisms for treating brain glioma and glioma stem cells via functionalized drug lipid vesicles. |
| URI | http://hdl.handle.net/20.500.11897/472806 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-017-03805-7 |
| Indexed | SCI(E) |
| Appears in Collections: | 天然药物与仿生药物国家重点实验室 药学院 |
