| Title | A History of Asthma From Childhood and Left Ventricular Mass in Asymptomatic Young Adults The Bogalusa Heart Study |
| Authors | Sun, Dianjianyi Wang, Tiange Heianza, Yoriko Lv, Jun Han, Liyuan Rabito, Felicia Kelly, Tanika Li, Shengxu He, Jiang Bazzano, Lydia Chen, Wei Qi, Lu |
| Affiliation | Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, 140 Canal St,Suite 1724, New Orleans, LA 70118 USA. Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Shanghai Inst Endocrine & Metabol Dis, Shanghai, Peoples R China. Peking Univ, Ctr Hlth Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China. Ningbo Univ, Sch Med, Dept Prevent Med, Zhejiang Prov Key Lab Pathophys, Ningbo, Peoples R China. Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA. Harvard Med Sch, Boston, MA 02115 USA. |
| Keywords | asthma left ventricular mass pre-hypertension OBSTRUCTIVE PULMONARY-DISEASE ELEVATED BLOOD-PRESSURE CARDIOVASCULAR-DISEASE ATHEROSCLEROSIS RISK ANGIOTENSIN-II LUNG-FUNCTION HYPERTROPHY HYPERTENSION COPD GEOMETRY |
| Issue Date | 2017 |
| Publisher | JACC-HEART FAILURE |
| Citation | JACC-HEART FAILURE.2017,5(7),497-504. |
| Abstract | OBJECTIVES This study aimed to examine whether a history of asthma from childhood is associated with left ventricular (LV) mass in adulthood. BACKGROUND Asthma has been related to various cardiovascular risk factors affecting LV hypertrophy. The authors saw a need for a prospective study to analyze the relationship between a history of asthma from childhood and markers of LV mass among asymptomatic young adults. METHODS Prospective analyses were performed among 1,118 Bogalusa Heart Study participants (average age at follow-up 36.7 +/- 5.1 years), with a baseline history of self-reported asthma collected since childhood ( average age at baseline 26.8 +/- 10.1 years). LV mass (g) was assessed using 2-dimensional guided M-mode echocardiography and was indexed for body height (m(2.7)) as LV mass index (LVMI; g/m(2.7)). A multivariate linear mixed model was fitted for the repeated measures. RESULTS After an average of 10.4 +/- 7.5 years of follow-up, participants with a history of asthma from childhood had a greater LV mass (167.6 vs. 156.9; p = 0.01) and LVMI (40.7 vs. 37.7; p < 0.01) with adjustment for age, sex, race, smoking status, antihypertensive medication, heart rate, and systolic blood pressure (SBP). The difference of LVMI between group with asthma and the group without asthma remained significant after additional adjustment for body mass index (39.0 vs. 37.1; p = 0.03) and high- sensitivity C-reactive protein (38.4 vs. 36.6; p = 0.04). In addition, the authors found significant interactions between SBP and asthma on LV mass and LVMI (p for interaction < 0.01, respectively). The associations between asthma and LV measures appeared to be stronger among pre-hypertensive and hypertensive participants (SBP >= 130 mm Hg) compared with participants with normal SBP (< 130 mm Hg) ( regression coefficient: 39.5 vs. 2.3 for LV mass and 9.0 vs. 0.9 for LVMI). CONCLUSIONS The findings of this study indicate that a history of asthma is associated with higher LVMI, and this association is stronger among participants with pre-hypertension and hypertension. (C) 2017 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. |
| URI | http://hdl.handle.net/20.500.11897/472510 |
| ISSN | 2213-1779 |
| DOI | 10.1016/j.jchf.2017.03.009 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
