| Title | Glutamatergic Projections from the Entorhinal Cortex to Dorsal Dentate Gyrus Mediate Context-Induced Reinstatement of Heroin Seeking |
| Authors | Ge, Feifei Wang, Na Cui, Cailian Li, Yijing Liu, Yan Ma, Yaoying Liu, Shuli Zhang, Haolin Sun, Xiaowei |
| Affiliation | Peking Univ, Dept Neurobiol, Sch Basic Med Sci, Key Lab Neurosci,Minist Educ, Beijing, Peoples R China. Peking Univ, Neurosci Res Inst, Natl Hlth & Family Planning Commiss, Beijing, Peoples R China. Peking Univ, Dept Neurobiol, Neurosci Res Inst, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | NUCLEUS-ACCUMBENS SHELL INDUCED COCAINE-SEEKING VENTRAL TEGMENTAL AREA NMDA RECEPTORS PREFRONTAL CORTEX SIGNALING PATHWAY NEUROPATHIC PAIN INDUCED RELAPSE MEMORY MORPHINE |
| Issue Date | 2017 |
| Publisher | NEUROPSYCHOPHARMACOLOGY |
| Citation | NEUROPSYCHOPHARMACOLOGY.2017,42(9),1860-1870. |
| Abstract | Reexposure to the context associated with heroin intake provokes relapse to drug taking after abstinence. The dorsal dentate gyrus (dDG) and entorhinal cortex (EC) have been implicated in contextual memory processing, but the underlying circuit mechanisms in context-induced relapse remain poorly understood. In this study, using a self-administration rat model, we found that activation and synaptic transmission of glutamatergic projections from the EC to the upper blade of dentate gyrus (dDG(ub)) were significantly enhanced during context-induced reinstatement of heroin seeking. This effect was associated with increased of phosphorylation of GluN2B-containing NMDA receptors (GluN2B) at Y1472, ratio of GluN2B membrane/total protein levels, and expression of downstream extracellular signal-regulated kinase-1/2 (ERK1/2) in the dDG region. Furthermore, DREADD-mediated specific inactivation of the EC-dDG pathway or disconnection of the pathway with local postsynaptic GluN2B-ERK1/2 signaling both decreased context-induced reinstatement of heroin seeking. These experimental manipulations had no effect on saccharin-reinforced responding and general locomotor activity in rats. Our results indicate that the EC-dDG pathway mediates context-induced reinstatement of heroin seeking, via the activation of postsynaptic GluN2B-ERK1/2 signaling in the dDG. |
| URI | http://hdl.handle.net/20.500.11897/471912 |
| ISSN | 0893-133X |
| DOI | 10.1038/npp.2017.14 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
