| Title | Abnormal Rich-Club Organization Associated with Compromised Cognitive Function in Patients with Schizophrenia and Their Unaffected Parents |
| Authors | Zhao, Xin Tian, Lin Yan, Jun Yue, Weihua Yan, Hao Zhang, Dai |
| Affiliation | Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China. Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China. Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China. Nanjing Med Univ, Wuxi Mental Hlth Ctr, Dept Psychiat, Wuxi 214151, Peoples R China. Wuxi Tongren Int Rehabil Hosp, Wuxi 214151, Peoples R China. Peking Univ, Tsinghua Univ, Joint Ctr Life Sci, PKU IDG,McGovern Inst Brain Res, Beijing 100871, Peoples R China. Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China. Yan, H Zhang, D (reprint author), Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China. Yan, H Zhang, D (reprint author), Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China. Zhang, D (reprint author), Peking Univ, Tsinghua Univ, Joint Ctr Life Sci, PKU IDG,McGovern Inst Brain Res, Beijing 100871, Peoples R China. |
| Keywords | Structural brain network Diffusion tensor imaging Rich-club Familial vulnerability Schizophrenia STRUCTURAL BRAIN NETWORKS FIBER INTEGRITY GENETIC-CONTROL CONNECTIVITY RISK RELATIVES CONNECTOMICS METAANALYSIS INDIVIDUALS CONSORTIUM |
| Issue Date | 2017 |
| Publisher | NEUROSCIENCE BULLETIN |
| Citation | NEUROSCIENCE BULLETIN.2017,33(4),445-454. |
| Abstract | Schizophrenia is considered to be a disorder of brain connectivity, which might result from a disproportionally impaired rich-club organization. The rich-club is composed of highly interconnected hub regions that play crucial roles in integrating information between different brain regions. Few studies have yet investigated whether the structural rich-club organization is impaired in patients and their first-degree relatives. In this study, we established a weighted network model of white matter connections using diffusion tensor imaging of 19 patients and 39 unaffected parents, 22 young healthy controls for the patients, and 25 old healthy controls for the parents. Feeder edges between rich-club nodes and non-rich-club nodes were significantly decreased in both schizophrenic patients and their unaffected parents compared with controls. Furthermore, the feeder edges showed significant positive correlations with the scores in Category Fluency Test-animal naming in the unaffected parents. Specific feeder edges exhibited discriminative power with accuracy of 84.4% in distinguishing unaffected parents from old healthy controls. Our findings suggest that impaired rich-club organization, especially impaired feeder edges, may be related to familial vulnerability to schizophrenia, possibly reflecting a genetic predisposition for schizophrenia. |
| URI | http://hdl.handle.net/20.500.11897/471855 |
| ISSN | 1673-7067 |
| DOI | 10.1007/s12264-017-0151-0 |
| Indexed | SCI(E) |
| Appears in Collections: | 第六医院 生命科学学院 |
