| Title | Endothelial activation and dysfunction in severe fever with thrombocytopenia syndrome |
| Authors | Li, Xiao-Kun Yang, Zhen-Dong Du, Juan Xing, Bo Cui, Ning Zhang, Pan-He Li, Hao Zhang, Xiao-Ai Lu, Qing-Bin Liu, Wei |
| Affiliation | Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China. 154 Hosp, Peoples Liberat Army, Xinyang, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing, Peoples R China. Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing, Peoples R China. Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China. Lu, QB (reprint author), Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing, Peoples R China. Lu, QB (reprint author), Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing, Peoples R China. |
| Keywords | DENGUE HEMORRHAGIC-FEVER INTERCELLULAR-ADHESION MOLECULE-1 SFTS VIRUS-INFECTION PROGNOSTIC VALUE CELLS EXPRESSION ICAM-1 CHINA |
| Issue Date | 2017 |
| Publisher | PLOS NEGLECTED TROPICAL DISEASES |
| Citation | PLOS NEGLECTED TROPICAL DISEASES.2017,11(8). |
| Abstract | Background Pathogenesis of severe fever with thrombocytopenia syndrome (SFTS) has not been well described yet. Recent studies indicate that SFTSV could replicate in endothelial cells. Here we performed a case-control study to determine whether endothelial activation/dysfunction occurred in SFTSV infection and to identify the biomarkers reflecting endothelial dysfunction. Methodology/Principal findings In a case-control study of 134 SFTS patients and 68 healthy controls, serum levels of plasminogen activator inhibitor 1, tissue plasminogen activator, P-selectin, platelet endothelial cell adhesion molecular, CD40 ligand, E-selectin, vascular endothelial growth factor A, serum amyloid antigen 1 (SAA-1) and vascular cell adhesion molecular 1 were significantly enhanced in the patients than the controls (all P<0.05), indicating the occurrence of endothelial activation/dysfunction in SFTS. The intercellular adhesion molecular 1 (ICAM-1) and SAA-1 at the convalescent phase were also significantly associated with severe patients, after adjusting for the potential confounders. The odds ratio was estimated to be 3.364 (95% CI 1.074-10.534) for ICAM-1, and 1.881 (95% CI 1.166-3.034) for SAA-1, respectively. Cutoff value of 1.1x10(7) pg/mL SAA-1 or 1.2x10(6) pg/mL ICAM-1 were found to have moderate power of predicting fatal cases. Conclusions The endothelial dysfunction may be one of the pathogenic mechanism of SFTS. The serum levels of ICAM-1 and SAA-1 might be used to predict adverse outcome. |
| URI | http://hdl.handle.net/20.500.11897/471637 |
| ISSN | 1935-2735 |
| DOI | 10.1371/journal.pntd.0005746 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
