| Title | Polymer-free dual drug-eluting stents evaluated in a porcine model |
| Authors | Zhang, Bin Zheng, Bo Wang, Xingang Shi, Qiuping Jia, Jia Huo, Yong Pan, Chunshui Han, Jingyan Chen, Ming |
| Affiliation | Peking Univ, Dept Cardiol, Hosp 1, 8 Xishiku Str, Beijing 100034, Peoples R China. Peking Univ, Dept Integrat Chinese & Western Med, Sch Basic Med Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China. Peking Univ, Dept Cardiol, Hosp 1, 8 Xishiku Str, Beijing 100034, Peoples R China. Han, JY (reprint author), Peking Univ, Dept Integrat Chinese & Western Med, Sch Basic Med Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China. Han, JY (reprint author), Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China. |
| Keywords | Stent thrombosis Endothelialization Probucol Optical coherence tomography Porcine CORONARY-ARTERY-DISEASE ENDOTHELIAL PROGENITOR CELLS RANDOMIZED-TRIAL FOLLOW-UP SIROLIMUS EFFICACY PROLIFERATION INFLAMMATION RESTENOSIS GENERATION |
| Issue Date | 2017 |
| Publisher | BMC CARDIOVASCULAR DISORDERS |
| Citation | BMC CARDIOVASCULAR DISORDERS.2017,17. |
| Abstract | Background: Although drug-eluting stents have dramatically reduced the rates of restenosis and target lesion revascularization, they are associated with stent thrombosis (ST), a catastrophic event likely due to delayed endothelialization and chronic inflammation caused by the polymer and the metal scaffolds. To increase the safety and efficacy of stents, polymer-free dual drug-eluting stents (DDES) have been developed. Methods: A total 160 stents (Bare-metal stents (BMS), polymer-free probucol stents (PrES), sirolimus-eluting stents (SES) and DDES) were randomly implanted in the coronary arteries of 80 pigs. 14, 28, 90 and 191 days after implantation, QCA and OCT evaluations were performed in 20 pigs respectively, and the arteries were harvested for scanning electron microscope (SEM), histomorphology, histopathology analyses and for the relative expression of CD31, CD34 and CD133 on mRNA and protein levels. Results: At the 14-day time point, there were significant differences in the strut rate coverage (p = 0.011), with greater coverage in the PrES than in the SES group (53.2% vs. 20.3%, p = 0.002). As well, there were no significant differences in the expression of CD31, CD34 and CD133 between groups in mRNA and protein level. Conclusions: DDES were as safe as BMS and SES, but they did not further improve the endothelialization of the stented coronary arteries in the porcine model. |
| URI | http://hdl.handle.net/20.500.11897/471465 |
| ISSN | 1471-2261 |
| DOI | 10.1186/s12872-017-0654-7 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 基础医学院 |
