| Title | Angupyrones A-E, alpha-Pyrone Analogues with ARE-Activation from a Sponge-Associated Fungus Truncatella angustata |
| Authors | Zhao, Yang Liu, Dong Proksch, Peter Yu, Siwang Lin, Wenhan |
| Affiliation | Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China. Heinrich Heine Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, DE-40225 Dusseldorf, Germany. |
| Keywords | Fungus Truncatella angustata Angupyrones A-E Structure elucidation ARE activation ASPERGILLUS-FUMIGATUS PENICILLIUM SP ACYL-COA INHIBITORS PYRIPYROPENES COUMARIN SERIES |
| Issue Date | 2017 |
| Publisher | CHEMISTRY & BIODIVERSITY |
| Citation | CHEMISTRY & BIODIVERSITY.2017,14(9). |
| Abstract | TLC-DPPH guided fractionation of a sponge-associated fungus Truncatella angustata with a solid culture resulted in the isolation of five new alpha-pyrone-based analogues namely angupyrones A-E (1-5), and 3-ethyl-4-hydroxy-6-methyl-2-pyrone. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method, bulkiness rule, and specific rotation for the configurational assignments. Angupyrones A-E exhibited moderate antioxidant response element activation in HepG2C8 cells, while the preliminary structure-activity relationship was discussed. |
| URI | http://hdl.handle.net/20.500.11897/471072 |
| ISSN | 1612-1872 |
| DOI | 10.1002/cbdv.201700236 |
| Indexed | SCI(E) |
| Appears in Collections: | 天然药物与仿生药物国家重点实验室 |
