| Title | The association between renal sinus fat area and the progression-free survival in Chinese non-metastatic clear-cell renal cell carcinoma patients |
| Authors | Huang, Haichao Chen, Shi Yu, Wei Ye, Zirong Li, Wei Xing, Jinchun Wu, Xiurong |
| Affiliation | Xiamen Univ, Dept Urol, Affiliated Hosp 1, Xiamen 361003, Fujian, Peoples R China. Xiamen Univ, Dept Radiol, Affiliated Hosp 1, Xiamen 361003, Fujian, Peoples R China. Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China. Peking Univ, Natl Urol Canc Ctr, Inst Urol, Beijing 100034, Peoples R China. Xiamen Univ, Sch Publ Hlth, Key Lab Hlth Technol Assessment Fujian Prov Univ, Xiamen 361005, Fujian, Peoples R China. Xiamen Univ, Dept Urol, Affiliated Hosp 1, Xiamen 361003, Fujian, Peoples R China. Wu, XR (reprint author), Xiamen Univ, Dept Radiol, Affiliated Hosp 1, Xiamen 361003, Fujian, Peoples R China. |
| Keywords | renal sinus fat progression survival non-metastatic renal cell carcinoma VISCERAL OBESITY RADICAL NEPHRECTOMY RISK HYPERTENSION PREDICTION STAGE SCORE |
| Issue Date | 2017 |
| Publisher | ONCOTARGET |
| Citation | ONCOTARGET.2017,8(39),65481-65491. |
| Abstract | In this retrospective study, we evaluated the association between renal sinus fat area (RSFA) and survival in 268 Chinese non-metastatic clear-cell renal cell carcinoma (ccRCC) patients. Patients with high RSFA exhibited better progression-free survival than those with low RSFA in both univariable (HR: 0.240; 95% CI: 0.119-0.482; p < 0.001) and multivariable (HR: 0.432; 95% CI: 0.369-2.749; p = 0.027) analyses. A propensity-score matched (PSM) analysis using Kaplan-Meier curves confirmed our findings (log-rank test; p = 0.028). Based on the multivariable analysis, we constructed a prognostic nomogram with 4 factors, namely, RSFA, Fuhrman grade, AJCC stage and sarcomatoid component. The c-index values for the Leibovich scoring system and the nomogram were 0.762 (95% CI, 0.688-0.835) and 0.823 (95% CI, 0.759-0.888), respectively. These findings demonstrate that high RSFA is associated with better progression-free survival in non-metastatic ccRCC. |
| URI | http://hdl.handle.net/20.500.11897/470889 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.19012 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
