| Title | Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma |
| Authors | Jin, Lu Fu, Huifang Quan, Jing Pan, Xiang He, Tao Hu, Jia Li, Yifan Li, Hang Yang, Yu Ye, Jing Zhang, Fangting Ni, Liangchao Yang, Shangqi Lai, Yongqing |
| Affiliation | Peking Univ, Shenzhen Hosp, Dept Urol, 1120 Lianhua Rd, Shenzhen 518036, Guangdong, Peoples R China. Anhui Med Univ, Dept Urol, Hefei 230032, Anhui, Peoples R China. Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen 518036, Guangdong, Peoples R China. Guangzhou Med Univ, Dept Urol, Guangzhou 511436, Guangdong, Peoples R China. |
| Keywords | long non-coding RNA renal tumor renal cell carcinoma differentiation antagonizing non-protein coding RNA TUMOR-SUPPRESSOR DOWN-REGULATION LNCRNA DANCR EXPRESSION CANCER IDENTIFICATION PATHWAY |
| Issue Date | 2017 |
| Publisher | MOLECULAR MEDICINE REPORTS |
| Citation | MOLECULAR MEDICINE REPORTS.2017,16(4),4463-4468. |
| Abstract | Renal cell carcinoma (RCC) is the third most common cancer in the urological system; however, the pathogenesis remains unknown. Accumulating evidence has demonstrated that long non-coding RNAs are dysregulated in various tumors and serves an important role in tumorigenesis and development. In the present study, expression of lncRNA differentiation antagonizing non-protein coding RNA (DANCR) in 24 paired RCC and adjacent normal tissues was detected by reverse transcription-quantitative polymerase chain reaction. The results revealed that DANCR is downregulated in RCC tissues compared with adjacent normal tissues. Subsequent study revealed that overexpression of lncRNA DANCR by transfection of pcDNA3.1-DANCR could suppress 786-O and ACHN (RCC cell) proliferation, migration and invasion, and induce apoptosis compared with cells transfected with the pcDNA3.1 vector. The results revealed that DANCR functions as a tumor suppressor in RCC. In conclusion, the present study, to the best of our knowledge, was the first to reveal DANCR as a tumor suppressor. The results implicate DANCR as a potential biomarker of RCC, and further study will be focused on the clinical significance and signaling pathways of DANCR. |
| URI | http://hdl.handle.net/20.500.11897/470646 |
| ISSN | 1791-2997 |
| DOI | 10.3892/mmr.2017.7135 |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
