| Title | PD-L1 and PD-1 expression are correlated with distinctive clinicopathological features in papillary thyroid carcinoma |
| Authors | Bai, Yanhua Niu, Dongfeng Huang, Xiaozheng Jia, Ling Kang, Qiang Dou, Fangyuan Ji, Xinqiang Xue, Weicheng Liu, Yiqiang Li, Zhongwu Feng, Qin Lin, Dongmei Kakudo, Kennichi |
| Affiliation | Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Pathol, 52 Fucheng Rd, Beijing 100142, Peoples R China. Peking Univ, Key Lab Carcinogenesis & Translat Res, Minist Educ, Dept Med Stat,Canc Hosp & Inst, 52 Fucheng Rd, Beijing 100142, Peoples R China. Kindai Univ, Fac Med, Nara Hosp, Dept Pathol, Ikoma City, Nara 6300293, Japan. |
| Keywords | BRAF V600E Chronic lymphocytic thyroiditis Papillary thyroid carcinoma PD-1 PD-L1 Tumor-infiltrating lymphocytes BRAF V600E MUTATION IMMUNOHISTOCHEMICAL DETECTION HASHIMOTOS-THYROIDITIS CELL INFILTRATION T-CELLS CANCER ANTIBODY ASSOCIATION BRAF(V600E) PROGNOSIS |
| Issue Date | 2017 |
| Publisher | DIAGNOSTIC PATHOLOGY |
| Citation | DIAGNOSTIC PATHOLOGY.2017,12. |
| Abstract | Background: Immune checkpoint blockade targeting PD-1/PD-L1 has shown efficacy in several types of cancers. However, the correlation between PD-L1/PD-1 expression and the specific clinicopathological features in papillary thyroid carcinoma (PTC) has not been investigated. Methods: We examined the immunohistochemical expression of PD-L1, PD-1, and BRAF V600E on whole-tissue sections from 126 cases of primary PTC more than 1 cm in size. The correlation between the PD-L1/PD-1 expression and the clinicopathological features was evaluated. Results: PD-L1 was positively expressed in 53.2% PTCs, and its expression was positively correlated with rich tumor-infiltrating lymphocytes (TILs), background chronic lymphocytic thyroiditis (CLT), female gender, absence of psammoma bodies, and PD-1 expression. Among these parameters, rich TILs, female gender, and absence of psammoma bodies were independent factors affecting PD-L1 expression on the multivariate logistic regression analysis. PD-1 expression was detected in the TILs and was positively correlated with rich TILs, background CLT, and absence of stromal calcification. Lack of stromal calcification was an independent factor affecting PD-1 expression. Neither PD-L1 nor PD-1 expression showed significant correlation with BRAF V600E expression. Conclusions: Our results show that the distinctive pathological features of PTCs, including TILs, background CLT, female gender, psammoma bodies, and stromal calcification, are useful parameters for predicting PD-L1 or PD-1 expression. |
| URI | http://hdl.handle.net/20.500.11897/470514 |
| ISSN | 1746-1596 |
| DOI | 10.1186/s13000-017-0662-z |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
