| Title | Verbal working memory-related functional connectivity alterations in boys with attention-deficit/hyperactivity disorder and the effects of methylphenidate |
| Authors | Wu, Zhao-Min Bralten, Janita An, Li Cao, Qing-Jiu Cao, Xiao-Hua Sun, Li Liu, Lu Yang, Li Mennes, Maarten Zang, Yu-Feng Franke, Barbara Hoogman, Martine Wang, Yu-Feng |
| Affiliation | Peking Univ, Natl Clin Res Ctr Mental Disorders, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China. Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China. Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands. Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands. Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China. Hangzhou Normal Univ, Affiliated Hosp, Hangzhou, Zhejiang, Peoples R China. Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China. Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Psychiat, Med Ctr, Nijmegen, Netherlands. Peking Univ, Hosp 6, Inst Mental Hlth, 51 Hua Yuan Bei Lu, Beijing 100191, Peoples R China. |
| Keywords | ADHD verbal working memory functional connectivity methylphenidate DEFICIT HYPERACTIVITY DISORDER REGIONAL BRAIN ACTIVATION STIMULANT MEDICATION PREFRONTAL CORTEX ADULT PATIENTS ICA-AROMA LIFE-SPAN ADHD CHILDREN FMRI |
| Issue Date | 2017 |
| Publisher | JOURNAL OF PSYCHOPHARMACOLOGY |
| Citation | JOURNAL OF PSYCHOPHARMACOLOGY.2017,31(8),1061-1069. |
| Abstract | Objective: Few studies have investigated verbal working memory-related functional connectivity patterns in participants with attention-deficit/hyperactivity disorder (ADHD). Thus, we aimed to compare working memory-related functional connectivity patterns in healthy children and those with ADHD, and study effects of methylphenidate (MPH). Method: Twenty-two boys with ADHD were scanned twice, under either MPH (single dose, 10 mg) or placebo, in a randomised, cross-over, counterbalanced placebo-controlled design. Thirty healthy boys were scanned once. We used fMRI during a numerical n-back task to examine functional connectivity patterns in case-control and MPH-placebo comparisons, using independent component analysis. Results: There was no significant difference in behavioural performance between children with ADHD, treated with MPH or placebo, and healthy controls. Compared with controls, participants with ADHD under placebo showed increased functional connectivity within fronto-parietal and auditory networks, and decreased functional connectivity within the executive control network. MPH normalized the altered functional connectivity pattern and significantly enhanced functional connectivity within the executive control network, though in non-overlapping areas. Conclusion: Our study contributes to the identification of the neural substrates of working memory. Single dose of MPH normalized the altered brain functional connectivity network, but had no enhancing effect on (non-impaired) behavioural performance. |
| URI | http://hdl.handle.net/20.500.11897/469050 |
| ISSN | 0269-8811 |
| DOI | 10.1177/0269881117715607 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 第六医院 |
