| Title | Biomechanical and histological evaluation of the osseointegration capacity of two types of zirconia implant |
| Authors | Han, Jian-min Hong, Guang Lin, Hong Shimizu, Yoshinaka Wu, Yuhan Zheng, Gang Zhang, Hongyu Sasaki, Keiichi |
| Affiliation | Peking Univ, Sch & Hosp Stomatol, Dept Dent Mat, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing, Peoples R China. Tohoku Univ, Div Adv Prosthet Dent, Sendai, Miyagi, Japan. Tohoku Univ, Liaison Ctr Innovat Dent, Sendai, Miyagi, Japan. Tohoku Univ, Grad Sch Dent, Dept Oral Pathol, Sendai, Miyagi, Japan. Tsinghua Univ, Dept Mech Engn, State Key Lab Tribol, Beijing, Peoples R China. Tohoku Univ, Grad Sch Dent, Liaison Ctr Innovat Dent, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan. |
| Keywords | zirconia dental implant zirconia-alumina nanocomposite push-in test histomorphometry OSTEOBLAST-LIKE CELLS TITANIUM IMPLANTS CE-TZP/AL2O3 NANOCOMPOSITE MICROSCOPIC OBSERVATIONS CERAMIC IMPLANTS SOFT-TISSUE IN-VITRO SURFACE BONE INTERFACE |
| Issue Date | 2016 |
| Publisher | International Journal of Nanomedicine |
| Citation | International Journal of Nanomedicine.2016,11,6507-6516. |
| Abstract | The purpose of this study was to evaluate the biomechanical and histological behavior of a ceria-stabilized zirconia-alumina nanocomposite (NanoZr) in comparison with that of 3 mol% yttria-stabilized tetragonal zirconia polycrystalline (3Y-TZP) in Sprague-Dawley rats. Cylindrical NanoZr and 3Y-TZP implants (diameter 1 mm, length 2 mm) were used. Implant-surface morphology and surface roughness were determined by scanning white-light interferometry and scanning electron microscopy, respectively. The cylindrical zirconia implants were placed at the distal edge of the femur of Sprague Dawley rats. At weeks 2, 4, and 8, the interfacial shear strength between implant and bone was measured by push-in test. Histological analysis was performed using hard-tissue sections. Bone-implant contact (BIC), the thickness of new bone around the implant within the bone marrow area, and osteoclast numbers were evaluated. The average surface roughness of 3Y-TZP (Sa 0.788 mu m) was significantly higher than that of NanoZr (Sa 0.559 mu m). The shear strengths of 3Y-TZP and NanoZr were similar at 2 weeks, but at 4 and 8 weeks the shear strength of NanoZr was higher than that of 3Y-TZP. The average BIC values within the bone marrow area for 3Y-TZP and NanoZr were 25.26% and 31.51% at 2 weeks, 46.78% and 38% at 4 weeks, and 47.88% and 56.81% at 8 weeks, respectively. The average BIC values within the cortical area were 38.86% and 58.42% at 2 weeks, 66.82% and 57.74% at 4 weeks, and 79.91% and 78.97% at 8 weeks, respectively. The mean BIC value did not differ significantly between the two zirconia materials at any time point. The NanoZr implants were biocompatible, capable of establishing close BIC, and may be preferred for metal-free dental implants. |
| URI | http://hdl.handle.net/20.500.11897/459141 |
| ISSN | 1178-2013 |
| DOI | 10.2147/IJN.S119519 |
| Indexed | SCI(E) |
| Appears in Collections: | 口腔医院 |
