| Title | Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage |
| Authors | Ge, Penglei Yang, Huayu Lu, Jingfen Liao, Wenjun Du, Shunda Xu, Yingli Xu, Haifeng Zhao, Haitao Lu, Xin Sang, Xinting Zhong, Shouxian Huang, Jiefu Mao, Yilei |
| Affiliation | Chinese Acad Med Sci, Peking Union Med Coll PUMC Hosp, Dept Liver Surg, Beijing, Peoples R China. PUMC, Beijing, Peoples R China. Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China. Chinese Acad Med Sci, Peking Union Med Coll PUMC Hosp, Dept Liver Surg, Beijing, Peoples R China. Mao, YL (reprint author), PUMC, Beijing, Peoples R China. |
| Keywords | NATURAL-HISTORY SERUM-ALBUMIN DISEASE EPIDEMIOLOGY CAPACITY |
| Issue Date | 2016 |
| Publisher | GASTROENTEROLOGY RESEARCH AND PRACTICE |
| Citation | GASTROENTEROLOGY RESEARCH AND PRACTICE.2016. |
| Abstract | Background. Currently there is no indicator that can evaluate actual liver lesion for early stages of viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and cirrhosis. Aim of this study was to investigate if albumin binding function could better reflect liver function in these liver diseases. Methods. An observational study was performed on 193 patients with early NAFLD, viral hepatitis, and cirrhosis. Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup. Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid binding capacity (total binding sites, TBS) were detected. Results. Both IMAT and TBS were significantly decreased in patients with NAFLD and early hepatitis. In hepatitis group, they declined prior to changes of liver enzymes. IMAT was significantly higher in cirrhosis Child-Pugh class A group than hepatitis patients and decreased in Child-Pugh class B and class C patients. Both IMAT/albumin and TBS/albumin decreased significantly in hepatitis and NAFLD group patients. Conclusions. This is the first study to discover changes of albumin metal ion and fatty acid binding capacities prior to conventional biomarkers for liver damage in early stage of liver diseases. They may become potential earliest sensitive indicators for liver function evaluation. |
| URI | http://hdl.handle.net/20.500.11897/459075 |
| ISSN | 1687-6121 |
| DOI | 10.1155/2016/5120760 |
| Indexed | SCI(E) |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
