| Title | CT-Guided I-125 Seed Interstitial Brachytherapy as a Salvage Treatment for Recurrent Spinal Metastases after External Beam Radiotherapy |
| Authors | Yao, Lihong Cao, Qianqian Wang, Junjie Yang, Jiwen Meng, Na Guo, Fuxin Jiang, Yuliang Tian, Suqing Sun, Haitao |
| Affiliation | Peking Univ, Hosp 3, Dept Radiat Oncol, Hua Yuan North Rd 49, Beijing 100191, Peoples R China. Shandong Univ, Ctr Canc, Hosp 2, Jinan 250033, Shandong, Peoples R China. Wannan Med Coll, Affiliated Hosp 1, Dept Nucl Med, 2 Zhe Shan Xi Rd, Jinghu Dist 241001, Wuhu, Peoples R China. |
| Keywords | STEREOTACTIC BODY RADIOTHERAPY RADIATION-THERAPY CORD COMPRESSION BONE METASTASES PERCUTANEOUS VERTEBROPLASTY IMPLANTATION TUMORS REIRRADIATION TOLERANCE CARCINOMA |
| Issue Date | 2016 |
| Publisher | BIOMED RESEARCH INTERNATIONAL |
| Citation | BIOMED RESEARCH INTERNATIONAL.2016. |
| Abstract | The aim of this study is to evaluate the feasibility, safety, and clinical efficacy of CT-guided I-125 seed interstitial brachytherapy in patients with recurrent spinal metastases after external beam radiotherapy (EBRT). Between August 2003 and September 2015, 26 spinal metastatic lesions (24 patients) were reirradiated by this salvage therapy modality. Treatment for all patients was preplanned using a three-dimensional treatment planning system 3-5 days before I-125 seed interstitial brachytherapy; dosimetry verification was performed immediately after seed implantation. Median actual D-90 was 99 Gy (range, 90-176), and spinal cord median D-max was 39 Gy (range, 6-110). Median local control (LC) was 12 months (95% CI: 7.0-17.0). The 6-and 12-month LC rates were 52% and 40%, respectively. Median overall survival (OS) was 11 months (95% CI: 7.7-14.3); 6- month and 1-, 2-, and 3-year OS rates were 65%, 37%, 14%, and 9%, respectively. Pain-free survival ranged from 2 to 42 months (median, 6; 95% CI: 4.6-7.4). Treatment was well-tolerated, with no radiation-induced vertebral compression fractures or myelopathy reported. Reirradiation with CT-guided I-125 seed interstitial brachytherapy appears to be feasible, safe, and effective as pain relief or salvage treatment for patients with recurrent spinal metastases after EBRT. |
| URI | http://hdl.handle.net/20.500.11897/459064 |
| ISSN | 2314-6133 |
| DOI | 10.1155/2016/8265907 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
