Title | Surgical management for non-functional pancreatic neuroendocrine neoplasms with synchronous liver metastasis: A consensus from the Chinese Study Group for Neuroendocrine Tumors (CSNET) |
Authors | Jin, Kaizhou Xu, Jin Chen, Jie Chen, Minhu Chen, Rufu Chen, Ye Chen, Zhiyu Cheng, Bin Chi, Yihebali Feng, Shi-Ting Fu, Deliang Hou, Baohua Huang, Dan Huang, Heguang Huang, Qiang Li, Jie Li, Ying Liang, Houjie Lin, Rong Liu, An'an Liu, Jixi Liu, Xubao Lu, Ming Lu, Jie Mai, Gang Ni, Quanxing Qiu, Meng Shao, Chenghao Shen, Baiyong Sheng, Weiqi Sun, Jian Tan, Chunlu Tan, Huangying Tang, Qiyun Tang, Yingmei Tian, Xiaodong Tong, Danian Wang, Xiaohong Wang, Jian Wang, Jie Wang, Wei Wang, Wei Wang, Yu Wu, Zheng Xue |
Affiliation | Fudan Univ, Shanghai Canc Ctr, Dept Pancreat Surg, 270 Dong An Rd, Shanghai 200032, Peoples R China. Fudan Univ, Pancreat Canc Inst, Shanghai, Peoples R China. Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou, Guangdong, Peoples R China. Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Biliary Pancreat Surg, Guangzhou, Guangdong, Peoples R China. Southern Med Univ, Nanfang Hosp, Dept Gastroenterol, Guangzhou, Guangdong, Peoples R China. Fudan Univ, Shanghai Canc Ctr, Dept Med Oncol, Shanghai, Peoples R China. Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gastroenterol, Tongji Med Coll, Wuhan, Hubei, Peoples R China. Chinese Acad Med Sci, Canc Inst & Hosp, Dept Med Oncol, Beijing, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiol, Guangzhou, Guangdong, Peoples R China. Fudan Univ, Huashan Hosp, Dept Pancreat Surg, Shanghai, Peoples R China. Guangdong Gen Hosp, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China. Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai, Peoples R China. Fujian Med Univ, Dept Gen Surg, Union Hosp, Fuzhou, Fujian, Peoples R China. Anhui Prov Hosp, Dept Gen Surg, Hefei, Anhui, Peoples R China. Peking Univ, Canc Hosp, Dept Gastrointestinal Oncol, Beijing, Peoples R China. Beijing Canc Hosp, Beijing, Peoples R China. Peking Univ, Canc Hosp, Dept Radiol, Beijing, Peoples R China. Third Mil Med Univ, Southwest Hosp, Dept Oncol, Chongqing, Peoples R China. Huazhong Univ Sci & Technol, Wuhan Union Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan, Hubei, Peoples R China. Second Mil Med Univ, Changzheng Hosp, Dept Gen Surg, Shanghai, Peoples R China. China Japan Friendship Hosp, Dept Gastroenterol, Beijing, Peoples R China. Sichuan Univ, West China Hosp, Dept Hepatobiliopancreat Surg, Chengdu, Sichuan, Peoples R China. China Japan Friendship Hosp, Dept Pathol, Beijing, Peoples R China. Peoples Hosp Deyang, Dept Hepatobiliopancreat Surg, Chengdu, Sichuan, Peoples R China. Sichuan Univ, West China Hosp, Ctr Canc, Dept Abdominal Oncol, Chengdu, Sichuan, Peoples R China. Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Gen Surg, Sch Med, Shanghai, Peoples R China. China Japan Friendship Hosp, Dept Integrat Oncol, Beijing, Peoples R China. Jiangsu Peoples Hosp, Dept Gastroenterol, Nanjing, Jiangsu, Peoples R China. Kunming Med Univ, Yunnan Res Ctr Liver Dis, Dept Gastroenterol, Affliated Hosp 2, Kunming, Yunnan, Peoples R China. Peking Univ, Dept Gen Surg, Hosp 1, Beijing, Peoples R China. Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Surg, Shanghai, Peoples R China. Fudan Univ, Shanghai Canc Ctr, Dept Radiol, Shanghai, Peoples R China. Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Biliary Pancreat Surg, Shanghai, Peoples R China. Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Hepatobiliary Surg, Guangzhou, Guangdong, Peoples R China. Fudan Univ, Huadong Hosp, Dept Surg, Shanghai, Peoples R China. Sun Yat Sen Univ, Dept Gastr & Pancreat Surg, Ctr Canc, Guangzhou, Guangdong, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Dept Intervent Oncol, Guangzhou, Guangdong, Peoples R China. Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian, Shaanxi, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pathol, Guangzhou, Guangdong, Peoples R China. Huzhou Cent Hosp, Dept Hepatobiliopancreat Surg, Huzhou, Zhejiang, Peoples R China. Eastern Hepatobiliary Surg Hosp, Hepatobiliary Surg Dept 5, Shanghai, Peoples R China. China Japan Friendship Hosp, Dept Hepatobiliary Surg, Beijing, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Dept Biliary Pancreat Surg, Guangzhou, Guangdong, Peoples R China. Peking Univ, Hosp 3, Dept Gen Surg, Beijing, Peoples R China. Cent S Univ, Xiangya Hosp, Dept Oncol, Changsha, Hunan, Peoples R China. Zhejiang Prov Peoples Hosp, Dept Gastrointestinal & Pancreat Surg, Hangzhou, Zhejiang, Peoples R China. |
Keywords | surgical managemerit non-functional pancreatic neuroendocrine neoplasms synchronous liver metastasis consensus Chinese Study Group for Neuroendocrine Tumors (CSNET) FINE-NEEDLE-ASPIRATION LONG-TERM SURVIVAL ENDOCRINE TUMORS HIGH-GRADE CARCINOID-TUMORS UNKNOWN PRIMARY ENDOSCOPIC ULTRASONOGRAPHY PROGNOSTIC-FACTORS PATIENT SELECTION LABELING INDEX |
Issue Date | 2016 |
Publisher | INTERNATIONAL JOURNAL OF ONCOLOGY |
Citation | INTERNATIONAL JOURNAL OF ONCOLOGY.2016,49(5),1991-2000. |
Abstract | Pancreatic neuroendocrine neoplasms (p-NENs) are slowly growing tumors with frequent liver metastasis. There is a variety of approaches to treat non-functional p-NENs with synchronous liver metastasis (LM) which complicates the determination of optimal treatment. Based on updated literature review, we discussed the treatment strategy determinants for p-NEN with LM. According to the resectability of primary tumor, the WHO 2010 grade classification and the radiological type of liver metastasis, the CSNET group reached agreements on a number of issues, including the following. Prior to treatment, biopsy is required to confirm pathology. Liver biopsy is important for more accurate grading of tumor and percutaneous core needle biopsy is more available than EUS-FNA. In patients with unresectable primary, surgical resection for liver-metastatic lesions should be avoided. Curative surgery is recommended for G1/G2 p-NET with type I LM and R1 resection also seems to improve overall survival rate. Cytoreductive surgery is recommended for G1G2 p-NET with type II LM in select patients, and should meet stated requirements. Surgical resection for G1G2 p-NET with type III LM and p-NEC with LM should be avoided, and insufficient evidence exists to guide the surgical treatment of G3 p-NET with LM. Liver transplantation may be an option in highly select patients. In addition, the optimal time for surgical approach is still required for more evidence. |
URI | http://hdl.handle.net/20.500.11897/458644 |
ISSN | 1019-6439 |
DOI | 10.3892/ijo.2016.3711 |
Indexed | SCI(E) |
Appears in Collections: | 北京肿瘤医院 第一医院 第三医院 |