| Title | Association between titanium and silver concentrations in maternal hair and risk of neural tube defects in offspring: A case-control study in north China |
| Authors | Li, Zhenjiang Huo, Wenhua Li, Zhiwen Wang, Bin Zhang, Jingxu Ren, Aiguo |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China. Peking Univ, Natl Hlth & Family Planning Commiss Peoples Repub, Key Lab Reprod Hlth, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Child Adolescent & Womens Hlth, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Inst Reprod & Child Hlth, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Neural tube defects NTDs Hair Titanium Silver DIOXIDE NANOPARTICLES TRACE-ELEMENTS HUMAN EXPOSURE BIRTH-DEFECTS HEAVY-METALS APOPTOSIS CELLS MICE FOOD NEUROTOXICITY |
| Issue Date | 2016 |
| Publisher | REPRODUCTIVE TOXICOLOGY |
| Citation | REPRODUCTIVE TOXICOLOGY.2016,66,115-121. |
| Abstract | Increasing uses of titanium and silver in various products raise concerns for their potential adverse effects on pregnancy outcomes. We aimed to examine the associations between titanium and silver concentrations in maternal hair growing during the periconception period and the risk of neural tube defects (NTDs) in offspring. Our case-control study recruited 191 women with NTD-affected pregnancies and 261 women delivering healthy infants. Metal concentrations in maternal hair were measured by inductively coupled plasma-mass spectrometry. The adjusted odds ratios (AOR) of titanium concentration above the median were 1.46 (95% confidence interval (CI), 0.99-2.13) for total NTDs and 2.10 (95% CI, 1.12-3.94) for anencephaly, while OR of silver wasn't statistically significant. Titanium concentration was positively correlated with consumptions of vegetables and fruits. Maternal exposure to titanium during the periconception period was associated with an increased NTD risk in offspring, which may be partly mediated through maternal dietary habits. (C) 2016 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/458285 |
| ISSN | 0890-6238 |
| DOI | 10.1016/j.reprotox.2016.10.006 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
