| Title | The MMP-7-181A/G gene polymorphism is a prognostic indicator in patients with gastric cancer |
| Authors | Cai, Xiu-Yu Guo, Jian-Gui Shen, Xiao-Ming Dong, Jun Hu, Wei-Han Guo, Gui-Fang He, Xiang-Zi Xia, Liang-Ping Hu, Pei-Li Qiu, Hui-Juan Liu, Shou-Sheng Zhou, Yi-Xin Rong, Yu-Ming Wang, Wei Dai, Ni Jiang, Wen-Qi Zhang, Bei |
| Affiliation | Sun Yat Sen Univ, State Key Lab Oncol South China, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. Sun Yat Sen Univ, Dept VIP Reg, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. Sun Yat Sen Univ, Radiat Dept, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. Sun Yat Sen Univ, Dept Radiol, Peoples Hosp Foshan 1, Affiliated Foshan Hosp, Foshan 528000, Peoples R China. Sun Yat Sen Univ, Dept Gastr Surg, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. Peking Univ, Sch Oncol, Dept Pathol, Beijing Canc Hosp, Beijing 100142, Peoples R China. Sun Yat Sen Univ, Dept Med Oncol, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. Sun Yat Sen Univ, State Key Lab Oncol South China, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. Zhang, B (reprint author), Sun Yat Sen Univ, Dept VIP Reg, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. Jiang, WQ (reprint author), Sun Yat Sen Univ, Dept Med Oncol, Ctr Canc, Guangzhou 510060, Guangdong, Peoples R China. |
| Keywords | MMP-7 gene polymorphism gastric cancer prognosis AND-9 PROMOTER POLYMORPHISMS MATRIX METALLOPROTEINASE-7 FUNCTIONAL POLYMORPHISMS LUNG-CANCER COLORECTAL-CANCER HELICOBACTER-PYLORI RISK EXPRESSION CARCINOMA SUSCEPTIBILITY |
| Issue Date | 2016 |
| Publisher | TRANSLATIONAL CANCER RESEARCH |
| Citation | TRANSLATIONAL CANCER RESEARCH.2016,5(6),748-755. |
| Abstract | Background: This study was designed to investigate the prognostic role of the MMP-7-181A/G gene polymorphism in patients with gastric cancer and to correlate the genotype with clinicopathological features. Methods: The polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) method was used to detect the MMP-7-181A/G gene polymorphism, and prognostic analyses were performed to elucidate the prognostic role of the gene polymorphism. Results: The MMP-7-181A/A genotype was detected in 83.8% (176/210) of cases, A/G genotype in 16.2% (34/210) of cases and G/G genotype in 0% (0/210) of cases. The MMP-7-181A/G polymorphism was closely correlated with lymph node metastasis (P = 0.037). A/G genotype carriers exhibit lymph node metastasis more frequently than A/A genotype carriers. The MMP-7-181A/G polymorphism was also strongly correlated with vascular invasion (P=0.003), and A/G genotype carriers show an increase in vascular invasion over A/A genotype carriers. The 5-year overall survival rates of A/A genotype carriers and A/G genotype carriers were 59.56% and 33.33%, respectively. The discrepancy was significant (P=0.0164). The prognosis of A/G genotype carriers was significantly worse than that of A/A genotype carriers. Multivariate survival analysis by Cox regression model confirmed that the MMP-7-181A/G genotype was an independent prognostic factor of gastric cancer (HR = 2.10; 95% CI: 1.09-4.05; P=0.027). Conclusions: The MMP-7-181A/G genotype was closely correlated with malignant biological behaviors and prognosis of gastric cancer. The MMP-7-181A/G genotype may serve as valuable prognostic indicator of gastric cancer. |
| URI | http://hdl.handle.net/20.500.11897/458156 |
| ISSN | 2218-676X |
| DOI | 10.21037/tcr.2016.10.04 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
