| Title | Genetic Evolution of Hepatitis E Virus |
| Authors | Zhang, Yulin Gong, Wanyun Zeng, Hang Wang, Ling |
| Affiliation | Peking Univ, Hlth Sci Ctr, Dept Microbiol, 38 Xueyuan Rd, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Sch Basic Med Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Dept Microbiol, 38 Xueyuan Rd, Beijing 100191, Peoples R China. Wang, L (reprint author), Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Sch Basic Med Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China. |
| Keywords | Genetic evolution Hepatitis E virus Mutant Open reading frame Genotype CIS-REACTIVE ELEMENT OPEN READING FRAME-2 CAPSID PROTEIN ORF3 PROTEIN HYPERVARIABLE REGION FAMILY HEPEVIRIDAE MUTATIONAL ANALYSIS ANTIBODY-RESPONSES CULTURED-CELLS VIRAL-RNA |
| Issue Date | 2016 |
| Publisher | HEPATITIS E VIRUS |
| Citation | HEPATITIS E VIRUS.2016,948,73-88. |
| Abstract | Comparative analysis of the genomic sequences of multiple hepatitis E virus (HEV) isolates has revealed extensive genomic diversity among them. Recently, a variety of genetically distinct HEV variants have also been isolated and identified from large numbers of animal species, including birds, rabbits, rats, ferrets, bats, cutthroat trout, and camels, among others. Furthermore, it has been reported that recombination in HEV genomes takes place in animals and in human patients. Also, chronic HEV infection in immunocompromised individuals has revealed the presence of viral strains carrying insertions from human genes. This paper reviews the current knowledge on the genomic variability and evolution of HEV. |
| URI | http://hdl.handle.net/20.500.11897/457441 |
| ISSN | 0065-2598 |
| DOI | 10.1007/978-94-024-0942-0_5 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 医学部待认领 |
