| Title | Chemotherapy Near the End of Life for Chinese Patients with Solid Malignancies |
| Authors | Sheng, Jin Zhang, Ya-Xiong He, Xiao-Bo Fang, Wen-Feng Yang, Yun-Peng Lin, Gui-Nan Wu, Xuan Li, Ning Zhang, Jing Zhai, Lin-Zhu Zhao, Yuan-Yuan Huang, Yan Zhou, Ning-Ning Zhao, Hong-Yun Zhang, Li |
| Affiliation | Sun Yat Sen Univ, Ctr Canc, Med Oncol, Guangzhou, Guangdong, Peoples R China. State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China. Collaborat Innovat Ctr Canc Med, Guangzhou, Guangdong, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 5, Dept Radiotherapy, Zhuhai, Peoples R China. Zhongshan City Peoples Hosp, Dept Med Oncol, Zhongshan, Peoples R China. Peking Univ, Dept Med Oncol, Shenzhen Hosp, Shenzhen, Peoples R China. Zhengzhou Univ, Affiliated Canc Hosp, Dept Med Oncol, Zhengzhou, Peoples R China. Henan Canc Hosp, Zhengzhou, Peoples R China. Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Med Oncol, Guangzhou, Guangdong, Peoples R China. |
| Keywords | End-of-life Palliative chemotherapy Advanced solid cancer CELL LUNG-CANCER EARLY PALLIATIVE CARE SINGLE-CENTER ANALYSIS QUALITY-OF-LIFE HEALTH-CARE AGGRESSIVENESS TRENDS SURVIVAL SYSTEM AGE |
| Issue Date | 2017 |
| Publisher | ONCOLOGIST |
| Citation | ONCOLOGIST.2017,22(1),53-60. |
| Abstract | Introduction. There are increasing concerns about the negative impacts of chemotherapy near the end of life (EOL). There is discrepancy among different countries about its use, and little is known about the real-world situation in China. Patients and Methods. This retrospective study was conducted at six representative hospitals across China. Adult decedents with a record of advanced solid cancer and palliative chemotherapy were consecutively screened from 2010 through 2014. The prevalence of EOL chemotherapy within the last 1 month of life was set as the primary outcome. The correlations among EOL chemotherapy, clinicopathological features, and overall survival (OS) were investigated. Results. A total of 3,350 decedents who had had cancer were consecutively included; 2,098 (62.6%) were male and the median age was 56 years (range, 20-88). There were 177 (5.3%), 387 (11.6%), and 837 (25.0%) patients who received EOL chemotherapy within the last 2 weeks, 1 month, and 2 months of life, respectively. We identified inferior OS (median OS, 7.1 vs. 14.2 months; hazard ratio, 1.37; 95% confidence interval [CI], 1.23-1.53; p < .001), more intensive treatments (e.g., admitted to intensive care unit [ICU] in the last month of life, received cardiopulmonary resuscitation and invasive ventilation support), and hospital death (odds ratio, 1.53; 95% CI, 1.14-2.06; p = .005) among patients who received continued chemotherapy within the lastmonth compared with those who did not. However, subgroup analyses indicated that receiving oral agents correlated with fewer ICU admissions and lower rates of in-hospital death. Conclusion. This study showed that EOL chemotherapy is commonly used in China. Intravenous chemotherapy at the EOL significantly correlated with poor outcomes and the role of oral anticancer agents warrants further investigation. Implications for Practice: The role of chemotherapy toward the end of life (EOL) in patients with solid cancers is debatable. This article is believed to be the first to report the current prevalence of EOL chemotherapy in China. This study found that, compared with oral anticancer agents, intravenous chemotherapy at the EOL was significantly associated with poor outcomes. Therefore, the role of oral anticancer agents at the EOL stage deserves further investigation. |
| URI | http://hdl.handle.net/20.500.11897/457210 |
| ISSN | 1083-7159 |
| DOI | 10.1634/theoncologist.2016-0013 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 深圳医院 |
