| Title | Autophagy substrate SQSTM1/p62 regulates chromatin ubiquitination during the DNA damage response |
| Authors | Wang, Yanan Zhu, Wei-Guo Zhao, Ying |
| Affiliation | Peking Univ, Beijing Key Lab Prot Posttranslat Modificat & Cel, Key Lab Carcinogenesis & Translat Res,Hlth Sci Ct, Minist Educ,Dept Biochem & Mol Biol,Sch Basic Med, Beijing 100191, Peoples R China. Peking Tsinghua Univ, Ctr Life Sci, Beijing, Peoples R China. Shenzhen Univ, Sch Med, Shenzhen, Peoples R China. |
| Keywords | autophagy DNA damage histone ubiquitination p62 RNF168 |
| Issue Date | 2017 |
| Publisher | AUTOPHAGY |
| Citation | AUTOPHAGY.2017,13(1),212-213. |
| Abstract | The importance of autophagy in the DNA damage repair process is clear; however, the detailed molecular mechanism is still largely unknown. Here we found that DNA damage-induced histone H2A ubiquitination is suppressed in autophagy-deficient cells in a SQSTM1/p62 dependent manner. SQSTM1 binds and inhibits E3 ligase RNF168s activity, which is essential for H2A ubiquitination. As a result, several important factors for DNA repair cannot be recruited to the sites of DNA double-strand breaks (DSBs) in autophagy-deficient cells, leading to diminished DNA repair and increased sensitivity of cells to radiation. |
| URI | http://hdl.handle.net/20.500.11897/457207 |
| ISSN | 1554-8627 |
| DOI | 10.1080/15548627.2016.1245262 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 基础医学院 |
