| Title | Assessment of growth and metabolism characteristics in offspring of dehydroepiandrosterone-induced polycystic ovary syndrome adults |
| Authors | Huang, Ying Gao, Jiang-Man Zhang, Chun-Mei Zhao, Hong-Cui Zhao, Yue Li, Rong Yu, Yong Qiao, Jie |
| Affiliation | Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing, Peoples R China. Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China. Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China. Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing, Peoples R China. Zhao, Y Yu, Y (reprint author), Minist Educ, Key Lab Assisted Reprod, Beijing, Peoples R China. Li, R Yu, Y (reprint author), Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing, Peoples R China. |
| Keywords | LIPID-METABOLISM ANDROGEN EXCESS INSULIN-RESISTANCE FEMALE RATS GENE-EXPRESSION SYNDROME PCOS PPAR-ALPHA MICE DAUGHTERS WOMEN |
| Issue Date | 2016 |
| Publisher | REPRODUCTION |
| Citation | REPRODUCTION.2016,152(6),705-714. |
| Abstract | Polycystic ovary syndrome (PCOS) is a common reproductive disorder that has many characteristic features including hyperandrogenemia, insulin resistance and obesity, which may have significant implications for pregnancy outcomes and long-term health of women. Daughters born to PCOS mothers constitute a high-risk group for metabolic and reproductive derangements, but no report has described potential growth and metabolic risk factors for such female offspring. Hence, we used a mouse model of dehydroepiandrosterone (DHEA)-induced PCOS to study the mechanisms underlying the pathology of PCOS by investigating the growth, developmental characteristics, metabolic indexes and expression profiles of key genes of offspring born to the models. We found that the average litter size was significantly smaller in the DHEA group, and female offspring had sustained higher body weight, increased body fat and triglyceride content in serum and liver; they also exhibited decreased energy expenditure, oxygen consumption and impaired glucose tolerance. Genes related to glucolipid metabolism such as Ppar., Acot1/2, Fgf21, Pdk4 and Inhbb were upregulated in the liver of the offspring in DHEA group compared with those in controls, whereas Cyp17a1 expression was significantly decreased. However, the expression of these genes was not detected in male offspring. Our results show that female offspring in DHEA group exhibit perturbed growth and glucolipid metabolism that were not observed in male offspring. |
| URI | http://hdl.handle.net/20.500.11897/457184 |
| ISSN | 1470-1626 |
| DOI | 10.1530/REP-16-0081 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 |
