| Title | Serotonin neurons in the dorsal raphe nucleus encode reward signals |
| Authors | Li, Yi Zhong, Weixin Wang, Daqing Feng, Qiru Liu, Zhixiang Zhou, Jingfeng Jia, Chunying Hu, Fei Zeng, Jiawei Guo, Qingchun Fu, Ling Luo, Minmin |
| Affiliation | Chinese Acad Med Sci, Grad Sch, Peking Union Med Coll, Beijing 100730, Peoples R China. Natl Inst Biol Sci, Zhongguancun Life Sci Pk 7,Sci Pk Rd, Beijing 102206, Peoples R China. Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China. Peking Univ, Sch Life Sci, PTN Grad Program, Beijing 100081, Peoples R China. Univ Sci & Technol, Wuhan Natl Lab Optoelect Huazhong, Britton Chance Ctr Biomed Photon, Wuhan 430074, Peoples R China. Chinese Acad Med Sci, Grad Sch, Peking Union Med Coll, Beijing 100730, Peoples R China. Luo, MM (reprint author), Natl Inst Biol Sci, Zhongguancun Life Sci Pk 7,Sci Pk Rd, Beijing 102206, Peoples R China. Luo, MM (reprint author), Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China. |
| Keywords | JUXTACELLULAR LABELING METHODS VENTRAL TEGMENTAL AREA PREFRONTAL CORTEX GABAERGIC NEURONS DELAYED REWARDS FIRING NEURONS ACTIVATION BRAIN RAT DOPAMINE |
| Issue Date | 2016 |
| Publisher | NATURE COMMUNICATIONS |
| Citation | NATURE COMMUNICATIONS.2016,7. |
| Abstract | The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours; however, it remains unclear how genetically defined neurons in the DRN of a freely behaving animal respond to various natural rewards. Here we addressed this question using fibre photometry and single-unit recording from serotonin (5-HT) neurons and GABA neurons in the DRN of behaving mice. Rewards including sucrose, food, sex and social interaction rapidly activate 5-HT neurons, but aversive stimuli including quinine and footshock do not. Both expected and unexpected rewards activate 5-HTneurons. After mice learn to wait for sucrose delivery, most 5-HT neurons fire tonically during waiting and then phasically on reward acquisition. Finally, GABA neurons are activated by aversive stimuli but inhibited when mice seek rewards. Thus, DRN 5-HT neurons positively encode a wide range of reward signals during anticipatory and consummatory phases of reward responses. Moreover, GABA neurons play a complementary role in reward processing. |
| URI | http://hdl.handle.net/20.500.11897/438970 |
| ISSN | 2041-1723 |
| DOI | 10.1038/ncomms10503 |
| Indexed | SCI(E) |
| Appears in Collections: | 生命科学学院 |
