| Title | Transportation in the Interstitial Space of the Brain Can Be Regulated by Neuronal Excitation |
| Authors | Shi, Chunyan Lei, Yiming Han, Hongbin Zuo, Long Yan, Junhao He, Qingyuan Yuan, Lan Liu, Huipo Xu, Ge Xu, Weiguo |
| Affiliation | Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China. Beijing Key Lab Magnet Resonance Imaging Technol, Beijing 100191, Peoples R China. Peking Univ, Sch Elect Engn & Comp Sci, Beijing 100871, Peoples R China. Peking Univ, Sch Basic Med Sci, Dept Anat & Histol, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Med & Hlth Anal Ctr, Beijing 100191, Peoples R China. Inst Appl Phys & Computat Math, Beijing 100094, Peoples R China. Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia. Natl Nat Sci Fdn China, Beijing 100085, Peoples R China. |
| Keywords | STIMULUS-INDUCED CHANGES EXTRACELLULAR-SPACE RAT-BRAIN IN-VIVO DOPAMINE RELEASE WATER DIFFUSION DRUG-DELIVERY GROWTH-FACTOR TIME-SERIES MRI |
| Issue Date | 2015 |
| Publisher | SCIENTIFIC REPORTS |
| Citation | SCIENTIFIC REPORTS.2015,5. |
| Abstract | The transportation of substances in the interstitial space (ISS) is crucial for the maintenance of brain homeostasis, however its link to neuronal activity remains unclear. Here, we report a marked reduction in substance transportation in the ISS after neuronal excitation. Using a tracer-based method, water molecules in the interstitial fluid (ISF) could be specifically visualized in magnetic resonance (MR) imaging. We first observed the flow of ISF in the thalamus and caudate nucleus of a rat. The ISF flow was then modulated using a painful stimulation model. We demonstrated that the flow of ISF slowed significantly following neuronal activity in the thalamus. This reduction in ISF flow continued for hours and was not accompanied by slow diffusion into the ISS. This observation suggests that the transportation of substances into the ISS can be regulated with a selective external stimulation. |
| URI | http://hdl.handle.net/20.500.11897/436020 |
| ISSN | 2045-2322 |
| DOI | 10.1038/srep17673 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 信息科学技术学院 基础医学院 |
