| Title | Multicentric epidemiologic study on six thousand three hundred and ninety five cases of femoral head osteonecrosis in China |
| Authors | Cui, Liqiang Zhuang, Qianyu Lin, Jin Jin, Jin Zhang, Ke Cao, Li Lin, Jianhao Yan, Shigui Guo, Wanshou He, Wei Pei, Fuxing Zhou, Yixin Weng, Xisheng |
| Affiliation | Beijing Union Med Coll Hosp, Dept Orthopaed, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China. Peking Univ, Dept Orthopaed, Hosp 3, North Garden Rd 49, Beijing 100191, Peoples R China. Xinjiang Med Univ, Dept Orthopaed, Teaching Hosp 1, South Liyushan St 137, Urumqi 830054, Xinjiang Prov, Peoples R China. Peking Univ, Dept Orthopaed, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China. Zhejiang Univ, Dept Orthopaed, Affiliated Hosp 1, Qingchun St 79, Hangzhou 310003, Zhejiang, Peoples R China. China Japan Friendship Hosp, Dept Orthopaed, 2 Yinghua Dongjie, Beijing 100029, Peoples R China. Guangzhou Univ Tradit Chinese Med, Dept Orthopaed, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China. Sichuan Univ, West China Hosp, Dept Orthopaed, 37 Guoxue St, Chengdu 610041, Sichuan, Peoples R China. Beijing Jishuitan Hosp, Dept Orthopaed, 31 Eastern Xinjiekou St, Beijing 100035, Peoples R China. |
| Keywords | Osteonecrosis of femoral head Etiology Risk factor IDIOPATHIC OSTEONECROSIS AVASCULAR NECROSIS NATURAL-HISTORY RISK |
| Issue Date | 2016 |
| Publisher | INTERNATIONAL ORTHOPAEDICS |
| Citation | INTERNATIONAL ORTHOPAEDICS.2016,40,(2),267-276. |
| Abstract | Purpose Osteonecrosis of femoral head (ONFH) is a common joint disease with high morbidity in mainland China. We performed a retrospective case investigation based on the widest range of patients ever to reveal the demographic and clinical characteristics of ONFH in mainland China. Methods We collected data from hospitalized patients of nine large tertiary hospitals in China, focusing on the aetiology of ONFH. Medical records and self-design questionnaires were used to collect data. We determined the patients' aetiology according to established guidelines and categorized patients into different subgroups. We further analysed the underlying illness of the steroid-induced osteonecrosis of femoral head. Results A total of 6,395 patients with complete medical records were included in the study. The age (mean +/- SD) of the patients was 46.45 +/- 13.80 years. Males dominate with 70.1 % of all ONFH patients. In all the ONFH patients, 24.1 % are steroid induced, 30.7 % are alcoholic, 16.4 % are traumatic and 28.8 % are idiopathic. Among steroid-induced osteonecrosis of femoral head patients, 546 patients have autoimmune disorder (46.63 %), which is the most common underling illness, among these, the most common disease is systemic lupus erythematosus (SLE). Conclusions The most common age when ONFH occurs is between 40 and 50 years old. Male patients developed ONFH 3.4 years earlier than female patients. The number of the male patients is greater than the female, reaching the overall gender proportion of 7:3. Autoimmune disease is the primary cause of steroid-induced ONFH, among which SLE is the most common disease. |
| URI | http://hdl.handle.net/20.500.11897/435903 |
| ISSN | 0341-2695 |
| DOI | 10.1007/s00264-015-3061-7 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第三医院 人民医院 |
