| Title | Correlation Between Platelet and Hemoglobin Levels and Pathological Characteristics and Prognosis of Early-Stage Squamous Cervical Carcinoma |
| Authors | Li, Xiaowei Tan, Cheng Zhang, Wanxuan Zhou, Jingyi Wang, Zhiqi Wang, Shijun Wang, Jianliu Wei, Lihui |
| Affiliation | Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China. |
| Keywords | Carcinoma, Squamous Cell Hemoglobin A Platelet Count GYNECOLOGIC-ONCOLOGY-GROUP PRETREATMENT THROMBOCYTOSIS NEOADJUVANT CHEMOTHERAPY RADICAL HYSTERECTOMY GASTRIC-CANCER GROWTH-FACTOR IMPACT SURVIVAL RADIOTHERAPY ASSOCIATION |
| Issue Date | 2015 |
| Publisher | MEDICAL SCIENCE MONITOR |
| Citation | MEDICAL SCIENCE MONITOR.2015,21,3921-3928. |
| Abstract | Background: We sought to determine the effect of pre-operative hemoglobin (HGB) and platelet (PLT) levels on the clinical features and prognosis of early-stage squamous cervical carcinoma (SCC). Material/Methods: We performed a retrospective analysis of 380 patients with SCC who underwent hysterectomy and pelvic lymphadenectomy. SCC was confirmed post-operatively by pathological diagnosis. The relations between HGB and PLT levels and clinicopathological characteristics were observed, and a Cox regression analysis was performed to determine their influence on survival. Results: There were significant differences in tumor staging, tumor diameter, and lymphatic metastasis between the 69 patients with PLT levels >300x10(9)/L and the 311 patients with PLT levels <= 300x10(9)/L (P<0.05). Tumor staging, extent of differentiation, and lymphatic metastasis were significantly different between 134 patients with HGB levels <120 g/L and 246 patients with HGB levels 3 120 g/L (P<0.05). The overall survival rate in the group with PLT levels >300x10(9)/L was lower than that in the group with PLT levels <= 300 x 10(9)/L, but this difference was not significant. The overall survival rate in the group with HGB levels <120 g/L was significantly lower than that in the group with HGB levels >= 120 g/L (P<0.05), and the overall survival rate in the group with PLT levels >300x10(9)/L and HGB levels <120 g/L was significantly lower than that in the group with PLT levels <= 300x10(9)/L and HGB levels >= 120 g/L (P<0.05). According to Cox regression analysis, a pre-operative HGB level <120 g/L was considered a separate risk factor affecting prognosis. Conclusions: Close attention must be paid to pre-operative PLT and HGB levels, and anemia should be remedied to facilitate the treatment of cervical carcinoma. |
| URI | http://hdl.handle.net/20.500.11897/435870 |
| ISSN | 1643-3750 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 |
