| Title | Human Adenovirus 36 Infection Increased the Risk of Obesity A Meta-Analysis Update |
| Authors | Xu, Mei-Yan Cao, Bing Wang, Dong-Fang Guo, Jing-Hui Chen, Kai-Li Shi, Mai Yin, Jian Lu, Qing-Bin |
| Affiliation | Aerosp Ctr Hosp, Dept Nutr, Beijing, Peoples R China. Peking Univ, Sch Publ Hlth, 38 Xue Yuan Rd, Beijing 100871, Peoples R China. Aerosp Ctr Hosp, Dept Ultrasound, Beijing, Peoples R China. Aerosp Ctr Hosp, Dept Resp, Beijing, Peoples R China. China Japan Friendship Hosp, Dept Clin Nutr, Beijing, Peoples R China. |
| Keywords | INSULIN-RESISTANCE ANTIBODY STATUS ADIPOSITY SEROPOSITIVITY CHILDREN ASSOCIATION ADULTS ADOLESCENTS CHICKEN WEIGHT |
| Issue Date | 2015 |
| Publisher | MEDICINE |
| Citation | MEDICINE.2015,94,(51). |
| Abstract | Human adenovints 36 (HAdV-36), as the key pathogen, was supposed and discussed to be associated with obesity. We searched the references on the association between HAdV-36 infection and obesity with the different epidemiological methods, to explore the relationship with a larger sample size by meta-analysis and compare the differences of epidemiological methods and population subsets by the subgroup analyses. We conducted literature search on the association between HAdV-36 infections and obesity in English or Chinese published up to July 1, 2015. The primary outcome was the HAdV-36 infection rate in the obese and lean groups; the secondary outcomes were the BMI level and BMI z-score in the HAdV-36 positive and negative groups. The pooled odds ratio (OR) was calculated for the primary outcome; the standardized mean differences (SMDs) were calculated for the secondary and third outcomes. Prediction interval (PI) was graphically presented in the forest plot of the random effect meta-analyses. Metaregression analysis and subgroup analysis were performed. Finally 24 references with 10,191 study subjects were included in the meta-analysis. The obesity subjects were more likely to be infected with HAdV-36 compared to the lean controls (OR = 2.00; 95%CI: 1.46, 2.74; PI: 0.59, 6.76; P < 0.001) with a high heterogeneity (I-2 = 80.1%; P < 0.001) estimated by the random effect model. Subgroup analysis demonstrated that the pooled OR of HAdV-36 infection for obesity were 1.77 (95%CI: 1.19, 2.63; PI: 0.44, 7.03; P=0.1)1)5) and 2.26 (95%CI: 1.67, 3.07; PI: 1.45, 3.54; P < 0.001) in the adults and children, respectively. Compared to the HAdV-36 negative subjects, the SMD of BMI was 0.28 (95% CI: 0.08, 0.47; PI: -0.53, 1.08; P=0.006) in the HAdV-36 positive subjects with a high heterogeneity (I-2=86.5%; P < 0.001). The BMI z-score in the children with HAdV-36 infection was higher than those without HAdV-36 infection (SMD = 0.19; 95%CI: -0.31, 0.70; PI: -2.10, 2.49), which had no significantly statistical difference (P=0.453). HAdV-36 infection increased the risk of obesity. HAdV-36 also increased the risk of weight gain in adults, which was not observed in children. |
| URI | http://hdl.handle.net/20.500.11897/435670 |
| ISSN | 0025-7974 |
| DOI | 10.1097/MD.0000000000002357 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 公共卫生学院 |
