| Title | Design and characterization of human exposure to generated sulfate and soot particles in a pilot chamber study |
| Authors | Chen, Xi Sun, Yitong Zhao, Qian Song, Xiaoming Huang, Wei Han, Yiqun Shang, Jing Zhu, Tong Wu, Aihua Luan, Shengji |
| Affiliation | Peking Univ, Inst Environm Med, Sch Publ Hlth, Beijing 100871, Peoples R China. Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China. Peking Univ, Coll Environm Sci & Engn, Beijing 100871, Peoples R China. Peking Univ, Hong Kong Univ Sci & Technol Shenzhen, HongKong Inst, Shenzhen Key Lab Environm Simulat & Pollut Contro, Shenzhen, Guangdong, Peoples R China. Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100871, Peoples R China. |
| Keywords | PARTICULATE AIR-POLLUTION EXHALED NITRIC-OXIDE SHORT-TERM EXPOSURE CONCENTRATED AMBIENT PARTICLES DIESEL EXHAUST INHALATION HEALTHY-YOUNG ADULTS ULTRAFINE PARTICLES BLACK CARBON CARDIOVASCULAR-DISEASE BEIJING OLYMPICS |
| Issue Date | 2016 |
| Publisher | JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION |
| Citation | JOURNAL OF THE AIR & WASTE MANAGEMENT ASSOCIATION.2016,66,(4),366-376. |
| Abstract | A number of literatures have documented adverse health effects of exposure to fine particulate matter (PM2.5), and secondary sulfate aerosol and black carbon may contribute to health impacts of PM2.5 exposure. We designed an exposure system to generate sulfate and traffic soot particles, and assessed the feasibility of using it for human exposure assessment in a pilot human exposure study. In the designed exposure system, average mass concentrations of generated sulfate and soot particles were 74.19 mu g/m(3) and 11.54 mu g/m(3) in the chamber and did not vary significantly during two-hour human exposure sessions. The size ranges of generated sulfate were largely between 20 to 200 nm, whereas those of generated soot particles were in the size ranges of 50 to 200nm. Following two-hour exposure to generated sulfate and soot particles, we observed significant increases in fractional exhaled NO (FeNO) in young and health subjects. Building on established human exposure system and health response follow-up methods, future full-scale studies focusing on the effects of mixed particulates and individual PM2.5 components would provide data in understanding the underpinning cardio-respiratory outcomes in relation to air pollution mixture exposure. Implications: Controlled exposure is a useful design to measure the biological responses repeatedly following particulate exposures of target components and set exposure at target levels of health concerns. Our study provides rational and establishes method for future full-scale studies to focus on examining the effects of mixed particulates and individual PM2.5 components. |
| URI | http://hdl.handle.net/20.500.11897/435528 |
| ISSN | 1096-2247 |
| DOI | 10.1080/10962247.2015.1136712 |
| Indexed | SCI(E) EI PubMed |
| Appears in Collections: | 公共卫生学院 环境科学与工程学院 环境模拟与污染控制国家重点联合实验室 |
