| Title | Prevalence of Obesity and Its Influence on Achievement of Cardiometabolic Therapeutic Goals in Chinese Type 2 Diabetes Patients: An Analysis of the Nationwide, Cross-Sectional 3B Study |
| Authors | Zhou, Xianghai Ji, Linong Ran, Xingwu Su, Benli Ji, Qiuhe Pan, Changyu Weng, Jianping Ma, Changsheng Hao, Chuanming Zhang, Danyi Hu, Dayi |
| Affiliation | Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100871, Peoples R China. Peking Univ, Ctr Diabet, Beijing 100871, Peoples R China. Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, Chengdu 610064, Peoples R China. Dalian Med Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Dalian, Peoples R China. Forth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol & Metab, Guangzhou 510275, Guangdong, Peoples R China. Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China. Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China. Fudan Univ, Huashan Hosp, Div Nephrol, Shanghai 200433, Peoples R China. Vital Strateg Res Inst, Berwyn, PA USA. Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China. |
| Keywords | BODY-MASS INDEX OPTIMAL CUTOFF POINTS RISK-FACTORS WEIGHT-LOSS CARDIOVASCULAR-DISEASES ADULTS ASSOCIATION MANAGEMENT MORTALITY MELLITUS |
| Issue Date | 2016 |
| Publisher | PLOS ONE |
| Citation | PLOS ONE.2016,11,(1). |
| Abstract | Background There are few data on the prevalence of obesity and its influence on achieving blood glucose, blood pressure, and blood lipid (3B) goals in Chinese type 2 diabetes outpatients. Methods Patient demographic data, anthropometric measurements, medications, and blood glucose and lipid profiles of 24,512 type 2 diabetes patients from a large, geographically diverse study (CCMR-3B) were analyzed. Using cut-points for body mass index (BMI) and waist circumference (WC) recommended by the Working Group on Obesity in China, overweight and obesity were defined as BMIs of 24-27.9kg/m(2) and >= 28.0kg/m(2). Central obesity was defined as a waist circumference >= 80cm in women and >= 85cm in men. The 3B therapeutic goals were HbA1c<7.0%, BP<140/90mmHg and LDL-C<2.6mmol/L. Results Overall, 43.0% of type 2 diabetes patients were overweight and 16.7% were obese; 13.3% of overweight and and 10.1% of obese patients achieved all the 3B target goals. Overweight or obese patients were less likely to achieve 3B goals than those with normal BMIs. More than a half the overweight or obese patients (69.6%) were centrally obese. Patients with abdominal obesity were less likely to achieve cardiometabolic targets than those without abdominal obesity. In multivariate logistic regression analysis, female, higher BMI and waist circumference, smoking, drinking, sedentary lifestyle, and longer diabetes duration were significantly correlated with failure to achieve 3B control goals. Conclusions Obesity is highly prevalent and associated with poor 3B control in Chinese type 2 diabetes patients. In clinical practice, more attention and resources should focus on weight loss for such patients. |
| URI | http://hdl.handle.net/20.500.11897/435526 |
| ISSN | 1932-6203 |
| DOI | 10.1371/journal.pone.0144179 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 人民医院 |
