| Title | Morphometric and hemodynamic analysis of atherosclerotic progression in human carotid artery bifurcations |
| Authors | Huang, Xu Yin, Xiaoping Xu, Yingjin Jia, Xinwei Li, Jianhui Niu, Pei Shen, Wenzeng Kassab, Ghassan S. Tan, Wenchang Huo, Yunlong |
| Affiliation | Peking Univ, Coll Engn, Dept Mech & Engn Sci, Beijing 100871, Peoples R China. Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing 100871, Peoples R China. Hebei Univ, Affiliated Hosp, Dept Radiol, Baoding, Peoples R China. Hebei Univ, Affiliated Hosp, Dept Internal Med, Baoding, Peoples R China. Hebei Univ, Affiliated Hosp, Dept Ultrason Funct, Baoding, Peoples R China. Hebei Univ, Coll Med, Baoding, Peoples R China. Calif Med Innovat Inst, San Diego, CA USA. Peking Univ, Shenzhen Grad Sch, Shenzhen, Peoples R China. |
| Keywords | carotid artery bifurcation stenosis atherosclerosis computed tomography angiography AMERICAN-HEART-ASSOCIATION FLOW PATTERNS SHEAR-STRESS VASCULAR-LESIONS GEOMETRY ANATOMY DISEASE RISK TREE ARTERIOSCLEROSIS |
| Issue Date | 2016 |
| Publisher | AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY |
| Citation | AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY.2016,310,(5),H639-H647. |
| Abstract | Although atherosclerosis has been widely investigated at carotid artery bifurcation, there is a lack of morphometric and hemodynamic data at different stages of the disease. The purpose of this study was to determine the lesion difference in patients with carotid artery disease compared with healthy control subjects. The three-dimensional (3D) geometry of carotid artery bifurcation was reconstructed from computed tomography angiography (CTA) images of Chinese control subjects (n = 30) and patients with carotid artery disease (n = 30). We defined two novel vector angles (i.e., angles 1 and 2) that were tangential to the reconstructed contour of the 3D vessel. The best-fit diameter was computed along the internal carotid artery (ICA) center line. Hemodynamic analysis was performed at various bifurcations. Patients with stenotic vessels have larger angles 1 and 2 (151 +/- 11 degrees and 42 +/- 20 degrees) and smaller diameters of the external carotid artery (ECA) (4.6 +/- 0.85 mm) compared with control subjects (144 +/- 13 degrees and 36 +/- 16 degrees, 5.2 +/- 0.57 mm) although there is no significant difference in the common carotid artery (CCA) (7.1 +/- 1.2 vs. 7.5 +/- 1.0 mm, P = 0.18). In particular, all patients with carotid artery disease have a stenosis at the proximal ICA (including both sinus and carina regions), while 20% of patients have stenosis at the middle ICA and 20% have stenosis expansion to the entire cervical ICA. Morphometric and hemodynamic analyses suggest that atherosclerotic plaques initiate at both sinus and carina regions of ICA and progress downstream. |
| URI | http://hdl.handle.net/20.500.11897/435447 |
| ISSN | 0363-6135 |
| DOI | 10.1152/ajpheart.00464.2015 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 工学院 深圳研究生院待认领 湍流与复杂系统国家重点实验室 |
