| Title | Association between Low Estimated Glomerular Filtration Rate and Risk of Cerebral Small-Vessel Diseases: A Meta-Analysis |
| Authors | Liu, Yuanyuan Lv, Pu Jin, Haiqiang Cui, Wei Niu, Chenguang Zhao, Mingming Fan, Chenghe Teng, Yuming Pan, Bing Peng, Qing Luo, Jingjing Zheng, Lemin Huang, Yining |
| Affiliation | Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China. Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Inst Syst Biomed, Sch Basic Med Sci, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China. Peking Univ, Hosp 1, Dept Neurol, Beijing 100034, Peoples R China. Zheng, LM (reprint author), Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100191, Peoples R China. Zheng, LM (reprint author), Peking Univ, Hlth Sci Ctr, Inst Syst Biomed, Sch Basic Med Sci, Beijing 100191, Peoples R China. Zheng, LM (reprint author), Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China. |
| Keywords | Cerebral small vessel diseases estimated glomerular filtration rate chronic kidney impairment meta-analysis CHRONIC KIDNEY-DISEASE WHITE-MATTER HYPERINTENSITY SILENT BRAIN INFARCTION ISCHEMIC-STROKE CARDIOVASCULAR-DISEASES BLOOD-PRESSURE RENAL-FUNCTION ETHNIC-GROUPS MICROBLEEDS PATHOGENESIS |
| Issue Date | 2016 |
| Publisher | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES |
| Citation | JOURNAL OF STROKE & CEREBROVASCULAR DISEASES.2016,25,(3),710-716. |
| Abstract | Background: Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs. Methods: Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented. Results: Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration. Conclusions: This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimated glomerular filtration was most strongly associated with SCI (OR = 2.71) among subtypes of CSVDs. |
| URI | http://hdl.handle.net/20.500.11897/435375 |
| ISSN | 1052-3057 |
| DOI | 10.1016/j.jstrokecerebrovasdis.2015.11.016 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 第一医院 |
