| Title | Transcriptional profiling analysis and functional prediction of long noncoding RNAs in cancer |
| Authors | Yuan, Jiao Yue, Haiyan Zhang, Meiying Luo, Jianjun Liu, Lihui Wu, Wei Xiao, Tengfei Chen, Xiaowei Chen, Xiaomin Zhang, Dongdong Xing, Rui Tong, Xin Wu, Nan Zhao, Jian Lu, Youyong Guo, Mingzhou Chen, Runsheng |
| Affiliation | Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China. Chinese Acad Sci, Inst Biophys, Beijing Key Lab Noncoding RNA, Beijing 100101, Peoples R China. Univ Chinese Acad Sci, Beijing 100049, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China. Peking Univ Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Mol Oncol Lab, Beijing 100142, Peoples R China. Med Sch Chinese PLA, PLA Gen Hosp Canc Ctr Key Lab, Beijing 100853, Peoples R China. Second Mil Med Univ, Int Joint Canc Inst, Shanghai 200433, Peoples R China. Chinese Acad Sci, Inst Biophys, Key Lab RNA Biol, Beijing 100101, Peoples R China. Chen, RS (reprint author), Chinese Acad Sci, Inst Biophys, Beijing Key Lab Noncoding RNA, Beijing 100101, Peoples R China. Guo, MZ (reprint author), Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing 100853, Peoples R China. Lu, YY (reprint author), Peking Univ Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Mol Oncol Lab, Beijing 100142, Peoples R China. Zhao, J (reprint author), Med Sch Chinese PLA, PLA Gen Hosp Canc Ctr Key Lab, Beijing 100853, Peoples R China. Zhao, J (reprint author), Second Mil Med Univ, Int Joint Canc Inst, Shanghai 200433, Peoples R China. |
| Keywords | IncRNA expression biomarker gastric cancer colon cancer PROSTATE-CANCER BREAST-CANCER EXPRESSION PROFILES INHIBITS MIGRATION GENES CELLS PHOSPHORYLATION DEFICIENCY BIOMARKERS LANDSCAPE |
| Issue Date | 2016 |
| Publisher | ONCOTARGET |
| Citation | ONCOTARGET.2016,7,(7),8131-8142. |
| Abstract | Long noncoding RNAs (lncRNAs), which are noncoding RNAs (ncRNAs) with length more than 200 nucleotides (nt), have been demonstrated to be involved in various types of cancer. Consequently, it has been frequently discussed that lncRNAs with aberrant expression in cancer serve as potential diagnostic biomarkers and therapeutic targets. However, one major challenge of developing cancer biomarkers is tumor heterogeneity which means that tumor cells show different cellular morphology, metastatic potential as well as gene expression. In this study, a custom designed microarray platform covering both mRNAs and lncRNAs was applied to tumor tissues of gastric, colon, liver and lung. 316 and 157 differentially expressed (DE-) protein coding genes and lncRNAs common to these four types of cancer were identified respectively. Besides, the functional roles of common DE-lncRNAs were inferred based on their expression and genomic position correlation with mRNAs. Moreover, mRNAs and lncRNAs with tissue specificity were also identified, suggesting their particular roles with regard to specific biogenesis and functions of different organs. Based on the large-scale survey of mRNAs and lncRNAs in four types of cancer, this study may offer new biomarkers common or specific for various types of cancer. |
| URI | http://hdl.handle.net/20.500.11897/435224 |
| ISSN | 1949-2553 |
| DOI | 10.18632/oncotarget.6993 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
