| Title | Bone marrow stromal cells induced activation of nuclear factor kappa B signaling protects non-Hodgkin's B lymphoma cells from apoptosis |
| Authors | Su, Tuo Li, Jiakai Meng, Mingming Zhao, Sheng Xu, Yali Ding, Xinmin Jiang, Hong Ma, Xiaorong Qian, Jin Han, Wei Sun, Lixin Li, Xiaobin Liu, Zuojun Pan, Lei Xue, Xinying |
| Affiliation | Capital Med Univ, Beijing Luhe Hosp, Dept Gen Surg, Beijing, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Gastroenterol, Beijing, Peoples R China. Peking Univ, Beijing Shijitan Hosp, Sch Clin Med 9, Dept Cardiol, Beijing, Peoples R China. Capital Med Univ, Beijing Shijitan Hosp, Dept Special Med Treatment, 10 Tieyi Rd, Beijing, Peoples R China. Capital Med Univ, Beijing Luhe Hosp, Dept Gen Surg, Beijing, Peoples R China. Pan, L Xue, XY (reprint author), Capital Med Univ, Beijing Shijitan Hosp, Dept Special Med Treatment, 10 Tieyi Rd, Beijing, Peoples R China. |
| Keywords | Bone marrow stromal cells Nuclear factor kappa B signaling Non-Hodgkin's B lymphoma cells Apoptosis TUMOR-SUPPRESSOR GENE MULTIPLE-MYELOMA UBIQUITIN LIGASE DIFFUSE EXPRESSION PATHWAY KINASE INACTIVATION DEREGULATION PATHOGENESIS |
| Issue Date | 2016 |
| Publisher | TUMOR BIOLOGY |
| Citation | TUMOR BIOLOGY.2016,37(8),10745-10752. |
| Abstract | The microenvironment encompassing a variety of non-malignant cells in close proximity with malignant tumor cells has been well known to significantly affect the behavior of tumor cells. In this study, we therefore studied the mechanism of bone marrow stromal cells in protection of lymphoma cells from spontaneous apoptosis. We demonstrated that adhesion of the freshly isolated lymphoma B cells to bone marrow stromal cells or freshly isolated lymphoma stromal cells inhibited B cell spontaneous apoptosis in culture. This inhibition of apoptosis correlated with decreased cleavage of caspase-3/8 and increased activation of canonical and non-canonical NF-kappa B signaling pathway. In addition to BAFF signaling which has been reported as a functional determinant for B lymphoma cell survival in the bone marrow environment, we demonstrated RANKL from BMSCs works synergistically with BAFF to activate NF-kappa B signaling pathway and thus protects lymphoma B cells from spontaneous apoptosis. |
| URI | http://hdl.handle.net/20.500.11897/434957 |
| ISSN | 1010-4283 |
| DOI | 10.1007/s13277-016-4860-1 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京世纪坛医院 |
