| Title | Cervical metastases of oral maxillary squamous cell carcinoma: A systematic review and meta-analysis |
| Authors | Zhang, Wen-Bo Peng, Xin |
| Affiliation | Peking Univ, Sch & Hosp Stomatol, Dept Oral & Maxillofacial Surg, 22 Zhongguancun Nandajie, Beijing 100871, Peoples R China. |
| Keywords | squamous cell carcinoma maxillary gingiva hard palate cervical metastases elective neck dissection ELECTIVE NECK DISSECTION CLINICALLY NEGATIVE NECK LYMPH-NODE METASTASES HARD PALATE RETROSPECTIVE ANALYSIS GINGIVAL CARCINOMA TONGUE CANCER ALVEOLUS CAVITY SURVIVAL |
| Issue Date | 2016 |
| Publisher | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK |
| Citation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK.2016,38,E2335-E2342. |
| Abstract | Cervical treatment of oral maxillary squamous cell carcinoma (SCC) remains controversial. We determined the metastases incidence and evaluated its predictive factors. Systematic review and meta-analysis was conducted of 23 Chinese and English-language articles retrieved from PubMed, Ovid, Embase, Cochrane Library, China National Knowledge Infrastructure, and Chinese Scientific and Technological Journal databases. Total cervical metastases and occult metastases rate was 32% and 21%, respectively. Positive lymph node detection was likeliest from levels I to III. The maxillary gingival metastases rate was higher than that of the hard palate. Advanced-stage tumors had higher metastatic risk than early-stage tumors. Well-differentiated tumors had a significantly higher metastases rate than medium and poor-differentiation tumors. N0 cases had survival benefit compared with N+ cases. Metastases rate of oral maxillary SCC correlates significantly with T classification and pathological stage. T and N classifications impact outcome significantly. Therefore, levels I to III selective neck dissection is recommended for patients with T3/4 cN0 disease. (C) 2016 Wiley Periodicals, Inc. |
| URI | http://hdl.handle.net/20.500.11897/434843 |
| ISSN | 1043-3074 |
| DOI | 10.1002/hed.24274 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 口腔医院 |
