| Title | Morbidity and Mortality of Laparoscopic Versus Open D2 Distal Gastrectomy for Advanced Gastric Cancer: A Randomized Controlled Trial |
| Authors | Hu, Yanfeng Huang, Changming Sun, Yihong Su, Xiangqian Cao, Hui Hu, Jiankun Xue, Yingwei Suo, Jian Tao, Kaixiong He, Xianli Wei, Hongbo Ying, Mingang Hu, Weiguo Du, Xiaohui Chen, Pingyan Liu, Hao Zheng, Chaohui Liu, Fenglin Yu, Jiang Li, Ziyu Zhao, Gang Chen, Xinzu Wang, Kuan Li, Ping Xing, Jiadi Li, Guoxin |
| Affiliation | Southern Med Univ, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China. Southern Med Univ, Guangzhou 510515, Guangdong, Peoples R China. Fujian Med Univ, Union Hosp, Fuzhou, Peoples R China. Fujian Prov Canc Hosp, Fuzhou, Peoples R China. Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China. Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai 200030, Peoples R China. Gen Hosp Peoples Liberat Army, Beijing, Peoples R China. Peking Univ, Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100871, Peoples R China. Sichuan Univ, West China Hosp, Chengdu 610064, Peoples R China. Harbin Med Univ, Affiliated Tumor Hosp, Harbin, Peoples R China. Jilin Univ, Hosp 1, Changchun 130023, Peoples R China. Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Wuhan 430074, Peoples R China. Fourth Mil Med Univ, Tangdu Hosp, Xian 710032, Peoples R China. Southern Med Univ, Nanfang Hosp, Dept Gen Surg, 1838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China. |
| Keywords | OPEN SUBTOTAL GASTRECTOMY ASSISTED GASTRECTOMY RETROSPECTIVE COHORT KOREAN MULTICENTER CLINICAL-TRIAL INTERIM-REPORT OUTCOMES LYMPHADENECTOMY DISSECTION COMPLICATIONS |
| Issue Date | 2016 |
| Publisher | JOURNAL OF CLINICAL ONCOLOGY |
| Citation | JOURNAL OF CLINICAL ONCOLOGY.2016,34,(12),1350-+. |
| Abstract | Purpose The safety and efficacy of radical laparoscopic distal gastrectomy (LG) with D2 lymphadenectomy for the treatment of advanced gastric cancer (AGC) remain controversial. We conducted a randomized controlled trial to compare laparoscopic and conventional open distal gastrectomy with D2 lymph node dissections for AGC. Patients and Methods Between September 2012 and December 2014, 1,056 patients with clinical stage T2-4aN0-3M0 gastric cancer were eligible for inclusion. They were randomly assigned to either the LG with D2 lymphadenectomy group (n = 528) or the open gastrectomy (OG) with D2 lymphadenectomy group (n = 528). Fifteen experienced surgeons from 14 institutions in China participated in the study. The morbidity and mortality within 30 days after surgery between the LG (n = 519) and the OG (n = 520) groups were compared on the basis of the modified intention-to-treat principle. Postoperative complications were stratified according to the Clavien-Dindo classification. Results The compliance rates of D2 lymphadenectomy were similar between the LG and OG groups (99.4% v 99.6%; P = .845). The postoperative morbidity was 15.2% in the LG group and 12.9% in OG group with no significant difference (difference, 2.3%; 95% CI, -1.9 to 6.6; P = .285). The mortality rate was 0.4% for the LG group and zero for the OG group (difference, 0.4%; 95% CI, -0.4 to 1.4; P = .249). The distribution of severity was similar between the two groups (P = .314). Conclusion Experienced surgeons can safely perform LG with D2 lymphadenectomy for AGC. (C) 2016 by American Society of Clinical Oncology |
| URI | http://hdl.handle.net/20.500.11897/434784 |
| ISSN | 0732-183X |
| DOI | 10.1200/JCO.2015.63.7215 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 北京肿瘤医院 |
