| Title | Failure recovery of circulating NKG2D(+)CD56(dim)NK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence |
| Authors | Gao, Jian Duan, Zhaojun Zhang, Ling Huang, Xiangbo Long, Lu Tu, Jing Liang, Hua Zhang, Yu Shen, Tao Lu, Fengmin |
| Affiliation | Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Microbiol, Hlth Sci Ctr, Beijing 100871, Peoples R China. Peking Univ, Infect Dis Ctr, Sch Basic Med, Hlth Sci Ctr, Beijing 100871, Peoples R China. Zhengzhou Univ, Dept Hepatobiliary & Pancreat Surg, Affiliated Tumor Hosp, Zhengzhou 450052, Peoples R China. Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Natl Ctr AIDS STD Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, Beijing, Peoples R China. Peking Univ, Dept Immunol, Hlth Sci Ctr, Beijing 100871, Peoples R China. Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Microbiol, Hlth Sci Ctr, Beijing 100871, Peoples R China. Shen, T Lu, FM (reprint author), Peking Univ, Infect Dis Ctr, Sch Basic Med, Hlth Sci Ctr, Beijing 100871, Peoples R China. |
| Keywords | HCC NK cells NKG2D sMICA TGF-beta NATURAL-KILLER-CELLS I-RELATED CHAIN NK CELLS TUMOR-CELLS LIVER RESECTION RISK-FACTORS LIGANDS IMPAIRMENT ACTIVATION EXPRESSION |
| Issue Date | 2016 |
| Publisher | ONCOIMMUNOLOGY |
| Citation | ONCOIMMUNOLOGY.2016,5,(1). |
| Abstract | Dysfunction of natural killer (NK) cells has been implicated in the failure of antitumor immune responses in hepatocellular carcinoma (HCC) patients. However, the changes of NK profile in peripheral blood after surgery and tumor tissues of HCC patients, as well as the underlying reason and the significance are vague. Here, we observed that the frequencies of circulating NKG2D(+)CD56(dim)NK cells decreased significantly in HBV-related HCC and were negatively correlated with the levels of serum TGF-beta and soluble MICA (sMICA). In vitro experiments confirmed that the TGF-b and sMICA in tumor tissue homogenates, as well as sMICA in HCC cells culture supernatants could reduce the frequency of NKG2D(+)CD56(dim)NK cells. In addition, in HCC patients the lower frequency of circulating NKG2D(+)CD56(dim)NK cells was associated with larger tumor size and/or higher serum GGT. Noticeably, the frequency of NKG2D(+)CD56(dim)NK cells at one month after surgery usually failed to restore in early recurrent patients, and that frequency was negatively associated with early recurrence and shorter overall survival. These results suggest that declined frequency of NKG2D(+)CD56(dim)NK cells in HCC was associated with higher TGF-b and sMICA production, and low frequency of circulating NKG2D(+)CD56(dim)NK cells at one month after surgery may predict poor prognosis of HBV-related HCC patients accepting hepatectomy. |
| URI | http://hdl.handle.net/20.500.11897/434638 |
| ISSN | 2162-402X |
| DOI | 10.1080/2162402X.2015.1048061 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 基础医学院 天然药物与仿生药物国家重点实验室 |
