| Title | Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling |
| Authors | Zhao, Shan Dai, Jianye Hu, Mo Liu, Chang Meng, Rong Liu, Xiaoyun Wang, Chu Luo, Tuoping |
| Affiliation | Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China. Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn, BNLMS,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China. Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China. Luo, TP (reprint author), Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn, BNLMS,Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China. |
| Keywords | CHEMISTRY FUNCTIONALIZATION CONJUGATION PROBES CELLS |
| Issue Date | 2016 |
| Publisher | CHEMICAL COMMUNICATIONS |
| Citation | CHEMICAL COMMUNICATIONS.2016,52,(25),4702-4705. |
| Abstract | The photo-induced reactions of diaryltetrazoles with carboxylic acids in aqueous solution were investigated. Besides measuring the apparent second-order rate constant and evaluating the functional group compatibility of these reactions, we further incorporated the tetrazoles into SAHA, leading to a new active-site-directed probe for labelling HDACs in both cell lysates and living cells. |
| URI | http://hdl.handle.net/20.500.11897/434591 |
| ISSN | 1359-7345 |
| DOI | 10.1039/c5cc10445a |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | 前沿交叉学科研究院 å å¦ä¸ å å å·¥ç¨ å¦é ¢ 生物有机与分子工程教育部重点实验室 |
