Title | DNA Sequential Logic Gate Using Two-Ring DNA |
Authors | Zhang, Cheng Shen, Linjing Liang, Chao Dong, Yafei Yang, Jing Xu, Jin |
Affiliation | Peking Univ, Minist Educ, Key Lab High Confidence Software Technol, Inst Software,Sch Elect Engn & Comp Sci, Beijing 100871, Peoples R China. Shannxi Normal Univ, Coll Life Sci, Xian 710062, Peoples R China. North China Elect Power Univ, Sch Control & Comp Engn, Beijing 102206, Peoples R China. Peking Univ, Minist Educ, Key Lab High Confidence Software Technol, Inst Software,Sch Elect Engn & Comp Sci, Beijing 100871, Peoples R China. Yang, J (reprint author), North China Elect Power Univ, Sch Control & Comp Engn, Beijing 102206, Peoples R China. |
Keywords | DNA logic gate sequential detection interlocked structure two-ring DNA gold nanoparticle STRAND-DISPLACEMENT-REACTIONS LABEL-FREE NANOSTRUCTURES CIRCUITS HYBRIDIZATION CONSTRUCTION COMPUTATION DNAZYME DEVICE MOTOR |
Issue Date | 2016 |
Publisher | ACS APPLIED MATERIALS & INTERFACES |
Citation | ACS APPLIED MATERIALS & INTERFACES.2016,8,(14),9370-9376. |
Abstract | Sequential DNA detection is a fundamental issue for elucidating the interactive relationships among complex gene systems. Here, a sequential logic DNA gate was achieved by utilizing the two-ring DNA structure, with the ability to recognize "before" and "after" triggering sequences of DNA signals. By taking advantage of a "loop-open" mechanism, separations of two-ring DNAs were controlled. Three triggering pathways with different sequential DNA treatments were distinguished by comparing fluorescent outputs. Programmed nanoparticle arrangement guided by "interlocked" two-ring DNA was also constructed to demonstrate the achievement of designed nanostrucutres. Such sequential logic DNA operation may guide future molecular sensors to monitor more complex gene network in biological systems. |
URI | http://hdl.handle.net/20.500.11897/434457 |
ISSN | 1944-8244 |
DOI | 10.1021/acsami.6b00847 |
Indexed | SCI(E) EI PubMed |
Appears in Collections: | 信息科学技术学院 高可信软件技术教育部重点实验室 |