| Title | Enhanced Anti-Tumor Efficacy through a Combination of Integrin alpha v beta 6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition |
| Authors | Gao, Liquan Zhang, Chenran Gao, Duo Liu, Hao Yu, Xinhe Lai, Jianhao Wang, Fan Lin, Jian Liu, Zhaofei |
| Affiliation | Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Med Isotopes Res Ctr, Beijing 100191, Peoples R China. Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China. Peking Univ, Coll Chem & Mol Engn, Synthet & Funct Biomol Ctr, Beijing 100871, Peoples R China. Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Med Isotopes Res Ctr, Beijing 100191, Peoples R China. Liu, ZF (reprint author), Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Radiat Med, Beijing 100191, Peoples R China. |
| Keywords | Molecular imaging Photodynamic therapy Checkpoint inhibition Tumor metastasis Combination therapy NEAR-INFRARED PHOTOIMMUNOTHERAPY CANCER-IMMUNOTHERAPY ANTI-CTLA-4 THERAPY PANCREATIC-CANCER TUMOR-MODEL METASTASIS BLOCKADE MELANOMA ANTIBODY CELLS |
| Issue Date | 2016 |
| Publisher | THERANOSTICS |
| Citation | THERANOSTICS.2016,6(5),627-637. |
| Abstract | "Training" the host immune system to recognize and systemically eliminate residual tumor lesions and micrometastases is a promising strategy for cancer therapy. In this study, we investigated whether integrin alpha v beta 6-targeted photodynamic therapy (PDT) of tumors using a phthalocyanine dye-labeled probe (termed DSAB-HK) could trigger the host immune response, and whether PDT in combination with anti-PD-1 immune checkpoint inhibition could be used for the effective therapy of primary tumors and metastases. By near-infrared fluorescence imaging, DSAB-HK was demonstrated to specifically target either subcutaneous tumors in a 4T1 mouse breast cancer model or firefly luciferase stably transfected 4T1 (4T1-fLuc) lung metastatic tumors. Upon light irradiation, PDT by DSAB-HK significantly inhibited the growth of subcutaneous 4T1 tumors, and in addition promoted the maturation of dendritic cells and their production of cytokines, which subsequently stimulated the tumor recruitment of CD8(+) cytotoxic T lymphocytes. Furthermore, DSAB-HK PDT of the first tumor followed by PD-1 blockade markedly suppressed the growth of a second subcutaneous tumor, and also slowed the growth of 4T1-fLuc lung metastasis as demonstrated by serial bioluminescence imaging. Together, our results demonstrated the synergistic effect of tumor-targeted PDT and immune checkpoint inhibition for improving anti-tumor immunity and suppressing tumor growth/metastasis. |
| URI | http://hdl.handle.net/20.500.11897/434343 |
| ISSN | 1838-7640 |
| DOI | 10.7150/thno.14792 |
| Indexed | SCI(E) PubMed |
| Appears in Collections: | å å¦ä¸ å å å·¥ç¨ å¦é ¢ 基础医学院 |
